SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype
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|Title||SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Giusti, S, Pagliari, F, Vozzi, F, Tirella, A, Mazzei, D, Cabiati, M, del Ry, S, Ahluwalia, A|
In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.