TitleSQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype
Publication TypeJournal Article
Year of Publication2013
AuthorsGiusti, S, Pagliari, F, Vozzi, F, Tirella, A, Mazzei, D, Cabiati, M, del Ry, S, Ahluwalia, A
JournalProcedia Engineering
Volume59
Pagination219–225
ISSN18777058
KeywordsBioengineering
Abstract

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S187770581301028X
DOI10.1016/j.proeng.2013.05.114