Biological tissues have highly complex and functional architectures. In order to construct engineered tissue with a high degree of complexity, cells must be provided with a suitable three dimensional synthetic or biological scaffolds upon which they can adhere and proliferate. We have developed and patented several microfabrication techniques, including PAM (Pressure Assisted MicroSyringe), PAM2 (Piston Assisted Microsyringe), integrated PAM2 modular fabrication system and SOFT-MI (soft molecular imprinting). In addition innovative molecular imprinting techniques are used to direct cell function at the nanoscale. Using our experience and facilities we are able to process different materials using also other methods present in our center such as Lithography, ink-jet system, microlaser system for ablation and sinterisation techiques and single-screw extrusion system. Combining all these different techniques it is possible realise complex structures with resolution from meso to nano scale combining different materials. The microfabrication systems are used in tissue engineering projects as well as for fabrication of sensors and actuators, and we can supply designer scaffolds of polymers and gels.
In parallel with the microfabrication and bioreactor research, we use modeling tools for designing and predicting the behaviour of particles, cells and drops in Microsystems.
Projects: MANUNET, Progetto San Paolo torino
Coordinator: Giovanni Vozzi
Team: Carmelo De Maria, Francesca Montemurro, Gianni Orsi, Francesca Gattazzo, Giuseppe Criscenti
Printing of bio-molecules or cells using ink-jet system
PAM2 modular micro-fabrication system
Smart scaffolds for monitoring cell process based on impedance characteristics