Biological tissues have highly complex and functional architectures. In order to construct engineered tissue with a high degree of complexity, cells must be provided with a suitable three dimensional synthetic or biological scaffolds upon which they can adhere and proliferate.

The Biofabrication Group aims at combining advanced fabrication technologies, including 3D printing, for creating scaffolds, in-vitro models, biosensors and actuators using smart and biomaterials. Applications are mainly focused on Tissue Engineering, regenerative medicine and biotechnologies.

The integration of 2D and 3D technologies are essential for fabricating complex structures using different material (including living cells) at different scales, from nanometers up to centimeters.

Between the different fabrication technologies, the group has a strong expertise in

  • Soft lithography, including the fabrication of microfluidic devices
  • Soft-MI, a technology patented by the group for imprinting the shape of molecules and cells onto a substrate
  • Electrospinning, for production of nanofibers matrices, with applications as scaffolds, but also fabrics, filters, and packaging
  • Fused deposition modelling, from filaments and pellet
  • Inkjet printing, for printing cells, nanoparticles and sensors

Simulation tools, including Finite Element Modelling and living cell metabolism mathematical models, and mechanical characterization are also part of the expertise of the group.

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Contacts

Coordinator: Giovanni Vozzi

Team: Carmelo De Maria, Francesca Montemurro, Aurora De Acutis, Anna Lapomarda

Social media channel: Twitter @BioFabUnipi

Contact: g.vozzi@centropiaggio.unipi.it

Video: https://www.youtube.com/watch?v=adbCa1sxinU&t=10s

 

Research Activities

 

Printing of bio-molecules or cells using ink-jet system

Biomembrane: Bioengineered in vitro model of retinal pigmented epithelium of human eye (Coordinator, M-ERA.NET EU Project)

Smart scaffolds for monitoring cell process based on impedance characteristics

 

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