%0 Journal Article %J Procedia Engineering %D 2013 %T SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype %A S. Giusti %A F. Pagliari %A Vozzi, F. %A Tirella, A %A D. Mazzei %A Cabiati, M %A S. del Ry %A A. Ahluwalia %K Bioengineering %X

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.

%B Procedia Engineering %V 59 %P 219–225 %G eng %U http://linkinghub.elsevier.com/retrieve/pii/S187770581301028X %R 10.1016/j.proeng.2013.05.114