TY - JOUR T1 - SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype JF - Procedia Engineering Y1 - 2013 A1 - S. Giusti A1 - F. Pagliari A1 - Vozzi, F. A1 - Tirella, A A1 - D. Mazzei A1 - Cabiati, M A1 - S. del Ry A1 - A. Ahluwalia KW - Bioengineering AB -

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.

VL - 59 UR - http://linkinghub.elsevier.com/retrieve/pii/S187770581301028X ER -