Decellularised tissue extracellular matrices (dECMs) can be finely minced and solubilised to obtain homogeneous hydrocolloids.

We have optimised a pepsin enzymatic digestion treatment to obtain homogeneous liver dECM pre-gel solutions that can form stable ECM gels via thermal gelation at 37 °C. This biocompatible crosslinking can occur even in presence of cells obtaining 3D cell-laden ECM hydrogels for a variety of applications ranging from in-vitro models to drug testing.

 

 

 

Contact info:

Ludovica CACOPARDO

Giorgio MATTEI 

Arti AHLUWALIA

 

 

Related publications:

In preparation.