Recreate the complexity of the natural extracellular matrix, and of tissues in general, is challanging. The purpose of the nano-in-micro concept is to assemble different and well characterised systems, trying to recreate part of such complexity.
Cells play an active role, and are considered as part of the nano-in-micro system.
Devices such as SpHyGa (Sphere Hydrogel Generator) or the NanoBioJet system are used to fabricate parts or assemblies of living and complex multi-scale systems. CFD and mathematical models are used to predict system behaviour and performance.
A. Tirella, M. La Marca, L-A Carroll, G. Mattei, J.W. Aylott and A. Ahluwalia, “Nano-In-Micro Self-Reporting Hydrogel Constructs”, Journal of Biomedical Nanotechnology, vol. 11, pp. 1451-1460, 2015
A. Tirella and Ahluwalia, A., “The impact of fabrication parameters and substrate stiffness in direct writing of living constructs”, Biotechnology progress, vol. 28, pp. 1315–1320, 2012
G. Mattei, A. Tirella and A. Ahluwalia, “Functionally Graded Materials (FGMs) with Predictable and Controlled Gradient Profiles: Computational Modelling and Realisation”, CMES: Computer Modeling in Engineering & Sciences, vol. 87, no. 6, pp. 483-504, 2012
A. Tirella et al., "Substrate stiffness influences high resolution printing of living cells with an ink-jet system", Journal of bioscience and bioengineering, vol. 112, pp. 79–85, 2011
A. Tirella et al., "PAM2 (Piston Assisted Microsyringe): A new rapid prototyping technique for biofabrication of cell incorporated scaffolds", Tissue Engineering Part C, vol 17, pp 229-237, 2011
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