@article {3349, title = {Systemic and vascular inflammation in an in-vitro model of central obesity}, journal = {PLoS ONE}, year = {2018}, month = {02/2018}, abstract = {

Metabolic disorders due to over-nutrition are a major global health problem, often associated with obesity and related morbidities. Obesity is peculiar to humans, as it is associated with lifestyle and diet, and so difficult to reproduce in animal models. Here we describe a model of human central adiposity based on a 3-tissue system consisting of a series of interconnected fluidic modules. Given the causal link between obesity and systemic inflammation, we focused primarily on pro-inflammatory markers, examining the similarities and differences between the 3-tissue model and evidence from human studies in the literature. When challenged with high levels of adiposity, the in-vitro system manifests cardiovascular stress through expression of E-selectin and von Willebrand factor as well as systemic inflammation (expressing IL-6 and MCP-1) as observed in humans. Interestingly, most of the responses are dependent on the synergic interaction between adiposity and the presence of multiple tissue types. The set-up has the potential to reduce animal experiments in obesity research and may help unravel specific cellular mechanisms which underlie tissue response to nutritional overload.

}, keywords = {Bioengineering}, doi = {https://doi.org/10.1371/journal.pone.0192824.s001}, url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192824}, author = {A. Ahluwalia and A. Misto and G. Vozzi and C. Magliaro and G. Mattei and Marescotti MC and AVOGARO, A and Iori, E.} } @article {2991, title = {On the adhesion-cohesion balance and oxygen consumption characteristics of liver organoids}, journal = {Plos One}, year = {2017}, month = {03/2017}, abstract = {

Liver organoids (LOs) are of interest in tissue replacement, hepatotoxicity and pathophysiological studies. However, it is still unclear what triggers LO self-assembly and what the optimal environment is for their culture. Hypothesizing that LO formation occurs as a result of a fine balance between cell-substrate adhesion and cell-cell cohesion, we used 3 cell types (hepatocytes, liver sinusoidal endothelial cells and mesenchymal stem cells) to investigate LO self-assembly on different substrates keeping the culture parameters (e.g. culture media, cell types/number) and substrate stiffness constant. As cellular spheroids may suffer from oxygen depletion in the core, we also sought to identify the optimal culture conditions for LOs in order to guarantee an adequate supply of oxygen during proliferation and differentiation. The oxygen consumption characteristics of LOs were measured using an O2 sensor and used to model the O2 concentration gradient in the organoids. We show that no LO formation occurs on highly adhesive hepatic extra-cellular matrix-based substrates, suggesting that cellular aggregation requires an optimal trade-off between the adhesiveness of a substrate and the cohesive forces between cells and that this balance is modulated by substrate mechanics. Thus, in addition to substrate stiffness, physicochemical properties, which are also critical for cell adhesion, play a role in LO self-assembly.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.1371/journal.pone.0173206}, url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173206}, author = {G. Mattei and C. Magliaro and S. Giusti and S. D. Ramachandran and S. Heinz and J. Braspenning and A. Ahluwalia} } @article {2928, title = {Allometric scaling in-vitro}, journal = {Scientific Reports}, volume = {7}, year = {2017}, month = {02/2017}, abstract = {

About two decades ago, West and coworkers established a model which predicts that metabolic rate follows a three quarter power relationship with the mass of an organism, based on the premise that tissues are supplied nutrients through a fractal distribution network. Quarter power scaling is widely considered a universal law of biology and it is generally accepted that were in-vitro cultures to obey allometric metabolic scaling, they would have more predictive potential and could, for instance, provide a viable substitute for animals in research. This paper outlines a theoretical and computational framework for establishing quarter power scaling in three-dimensional spherical constructs in-vitro, starting where fractal distribution ends. Allometric scaling in non-vascular spherical tissue constructs was assessed using models of Michaelis Menten oxygen consumption and diffusion. The models demonstrate that physiological scaling is maintained when about 5 to 60\% of the construct is exposed to oxygen concentrations less than the Michaelis Menten constant, with a significant concentration gradient in the sphere. The results have important implications for the design of downscaled in-vitro systems with physiological relevance.

}, keywords = {Bioengineering}, doi = {10.1038/srep42113}, url = {http://www.nature.com/articles/srep42113}, author = {A. Ahluwalia} } @article {3124, title = {Decellularized Human Liver Is Too Heterogeneous for Designing a Generic Extracellular Matrix Mimic Hepatic Scaffold.}, journal = {Artificial Organs}, year = {2017}, month = {05/2017}, abstract = {

Decellularized human livers are considered the\ perfect extracellular matrix (ECM) surrogate because both three-dimensional architecture and biological features of the hepatic microenvironment are thought to be preserved. However, donor human livers are in chronically short supply, both for transplantation or as decellularized scaffolds, and will become even scarcer as life expectancy increases. It is hence of interest to determine the structural and biochemical properties of human hepatic ECM to derive design criteria for engineering biomimetic scaffolds. The intention of this work was to obtain quantitative design specifications for fabricating scaffolds for hepatic tissue engineering using human livers as a template. To this end, hepatic samples from five patients scheduled for hepatic resection were decellularized using a protocol shown to reproducibly conserve matrix composition and microstructure in porcine livers. The decellularization outcome was evaluated through histological and quantitative image analyses to evaluate cell removal, protein, and glycosaminoglycan content per unit area. Applying the same decellularization protocol to human liver samples obtained from five different patients yielded five different outcomes. Only one liver out of five was completely decellularized, while the other four showed different levels of remaining cells and matrix. Moreover, protein and glycosaminoglycan content per unit area after decellularization were also found to be patient- (or donor-) dependent. This donor-to-donor variability of human livers thus precludes their use as templates for engineering a generic "one-size fits all" ECM-mimic hepatic scaffold.

}, keywords = {Bioengineering}, doi = {10.1111/aor.12925.}, url = {https://www.ncbi.nlm.nih.gov/pubmed/28543403}, author = {G. Mattei and C. Magliaro and Pirone, A. and A. Ahluwalia} } @article {3246, title = {Assessment of spontaneous cardiovascular oscillations in Parkinson{\textquoteright}s disease}, journal = {Biomedical Signal Processing and Control}, volume = {26}, year = {2016}, pages = {80{\textendash}89}, keywords = {Bioengineering}, author = {G. Valenza and S. Orsolini and S. Diciotti and L. Citi and E. P. Scilingo and M. Guerrisi and S. Danti and C. Lucetti and C. Tessa and R. Barbieri} } @article {2835, title = {Clarifying CLARITY: Quantitative Optimization of the Diffusion Based Delipidation Protocol for Genetically Labeled Tissue}, journal = {Frontiers in Neuroscience}, year = {2016}, abstract = {

Tissue clarification has been recently proposed to allow deep tissue imaging without light scattering. The clarification parameters are somewhat arbitrary and dependent on tissue type, source and dimension: every laboratory has its own protocol, but a quantitative approach to determine the optimum clearing time is still lacking. Since the use of transgenic mouse lines that express fluorescent proteins to visualize specific cell populations is widespread, a quantitative approach to determine the optimum clearing time for genetically labeled neurons from thick murine brain slices using CLARITY2 is described. In particular, as the main objective of the delipidation treatment is to clarify tissues, while limiting loss of fluorescent signal, the {\textquotedblleft}goodness{\textquotedblright} of clarification was evaluated by considering the bulk tissue clarification index (BTCi) and the fraction of the fluorescent marker retained in the slice as easily quantifiable macroscale parameters. Here we describe the approach, illustrating an example of how it can be used to determine the optimum clearing time for 1 mm-thick cerebellar slice from transgenic L7GFP mice, in which Purkinje neurons express the GFP (green fluorescent protein) tag. To validate the method, we evaluated confocal stacks of our samples using standard image processing indices (i.e., the mean pixel intensity of neurons and the contrast-to-noise ratio) as figures of merit for image quality. The results show that detergent-based delipidation for more than 5 days does not increase tissue clarity but the fraction of GFP in the tissue continues to diminish. The optimum clearing time for 1 mm-thick slices was thus identified as 5 days, which is the best compromise between the increase in light penetration depth due to removal of lipids and a decrease in fluorescent signal as a consequence of protein loss: further clearing does not improve tissue transparency, but only leads to more protein removal or degradation. The rigorous quantitative approach described can be generalized to any clarification method to identify the moment when the clearing process should be terminated to avoid useless protein loss.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.3389/fnins.2016.00179}, url = {http://journal.frontiersin.org/article/10.3389/fnins.2016.00179/full}, author = {C. Magliaro and A. L. Callara and G. Mattei and M. Morcinelli and C. Viaggi and Vaglini, F and A. Ahluwalia} } @article {3252, title = {Combining electroencephalographic activity and instantaneous heart rate for assessing brain{\textendash}heart dynamics during visual emotional elicitation in healthy subjects}, journal = {Phil. Trans. R. Soc. A}, volume = {374}, year = {2016}, pages = {20150176}, keywords = {Bioengineering}, author = {G. Valenza and A. Greco and C. Gentili and A. Lanat{\`a} and Sebastiani, L. and D. Menicucci and A. Gemignani and E. P. Scilingo} } @article {2710, title = {fabrication and perivascular implantation of bioactive scaffolds engineered with human adventitial progenitor cells for stimulation of arteriogenesis in peripheral ischemia}, journal = {Biofabrication}, volume = {8}, year = {2016}, month = {03/24}, keywords = {Bioengineering}, doi = {10.1088/1758-5090/8/1/015020}, author = {Carrabba, M. and C. De Maria and A. Oikawa and C. Reni and I. Rodriguez-Arabaolaza and H. Spencer and S. Slater and E. Avolio and Z. Dang and G. Spinetti and MADEDDU, P. and G. Vozzi} } @inbook {2714, title = {A Full Body Sensing System for Monitoring Stroke Patients in a Home Environment}, booktitle = {Biomedical Engineering Systems and Technologies: 7th International Joint Conference, BIOSTEC 2014, Angers, France, March 3-6, 2014, Revised Selected Papers}, year = {2016}, pages = {378 - 393}, publisher = {Springer International Publishing}, organization = {Springer International Publishing}, keywords = {Bioengineering}, isbn = {978-3-319-26128-7}, doi = {10.1007/978-3-319-26129-4_25}, author = {Klaassen, B. and van Beijnum, B.J.F. and Weusthof, M. H. H. and D. Hofs and van Meulen, F.B. and E. Droog and H. Luinge and S. Laurens and A. Tognetti and F. Lorussi and R. Paradiso and Held, J. and Luft, A. R. L. and Reenalda, J. and Nikamp, C. D. M. and Buurke, J. H. and Hermens, HJ and Veltink, P.} } @article {3253, title = {The heart side of brain neuromodulation}, journal = {Phil. Trans. R. Soc. A}, volume = {374}, year = {2016}, pages = {20150187}, keywords = {Bioengineering}, author = {S. Rossi and E. Santarnecchi and G. Valenza and M. Ulivelli} } @article {2496, title = {The influence of mesh topology in the abdominal wall repair process}, journal = {J Biomed Mater Res Part B. }, year = {2016}, month = {08/2016}, keywords = {Bioengineering}, doi = {https://doi.org/10.1002/jbm.b.33468}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26097153}, author = {C. De Maria and S. Burchielli and C. Salvadori and V. Santoro and F. Montemurro and G. Orsi and G. Vozzi} } @article {3255, title = {Inhomogeneous point-processes to instantaneously assess affective haptic perception through heartbeat dynamics information}, journal = {Scientific reports}, volume = {6}, year = {2016}, keywords = {Bioengineering}, author = {G. Valenza and A. Greco and L. Citi and M. Bianchi and R. Barbieri and E. P. Scilingo} } @article {2834, title = {Polymeric microporous nanofilms as smart platforms for in vitro assessment of nanoparticle translocation and Caco-2 cell culture}, journal = { IEEE Transactions on NanoBioscience }, year = {2016}, keywords = {Bioengineering}, doi = { 10.1109/TNB.2016.2603191}, url = {http://ieeexplore.ieee.org/document/7552480/}, author = {L. Ricotti and G. Gori and D. Cei and J. Costa and G. Signore and A. Ahluwalia} } @article {3254, title = {Predicting Mood Changes in Bipolar Disorder through Heartbeat Nonlinear Dynamics}, journal = {IEEE Journal of Biomedical and Health Informatics}, year = {2016}, keywords = {Bioengineering}, author = {G. Valenza and M. Nardelli and C. Gentili and G. Bertschy and M. Kosel and E. P. Scilingo} } @article {2711, title = {Reconstruction of medial patello-femoral ligament: Comparison of two surgical techniques}, journal = {J Mech Behav Biomed Mater.}, year = {2016}, month = {02/10}, pages = {272-278}, keywords = {Bioengineering}, doi = {10.1016/j.jmbbm.2016.02.009}, author = {Criscenti, G. and C. De Maria and E. Sebastiani and M. Tei and G. Placella and G. Vozzi and Cerulli, G.} } @article {3241, title = {Relationship between cardiac vagal activity and mood congruent memory bias in major depression}, journal = {Journal of Affective Disorders}, volume = {190}, year = {2016}, pages = {19{\textendash}25}, keywords = {Bioengineering}, author = {R. G. Garcia and G. Valenza and C. A. Tomaz and R. Barbieri} } @article {2833, title = {Sample, testing and analysis variables affecting liver mechanical properties: A review}, journal = {Acta Biomaterialia}, year = {2016}, abstract = {

Given the critical role of liver mechanics in regulating cell response and directing the development of tissue fibrosis, accurately characterising its mechanical behaviour is of relevance for both diagnostic purposes as well as for tissue engineering and for the development of in-vitro models. Determining and quantifying the mechanical behaviour of soft biological tissues is, however, highly challenging due to their intrinsic labile nature. Indeed, a unique set of values of liver mechanical properties is still lacking to date; testing conditions can significantly affect sample status and hence the measured behaviour and reported results are strongly dependent on the adopted testing method and configuration as well as sample type and status. This review aims at summarising the bulk mechanical properties of liver described in the literature, discussing the possible sources of variation and their implications on the reported results. We distinguish between the intrinsic mechanical behaviour of hepatic tissue, which depends on sample variables, and the measured mechanical properties which also depend on the testing and analysis methods. Finally, the review provides guidelines on tissue preparation and testing conditions for generating reproducible data which can be meaningfully compared across laboratories.

}, keywords = {Bioengineering}, doi = { http://dx.doi.org/10.1016/j.actbio.2016.08.055}, url = {http://www.sciencedirect.com/science/article/pii/S1742706116304603}, author = {A. Ahluwalia and G. Mattei} } @conference {2820, title = {Tactile Augmented Reality for Arteries Palpation in Open Surgery Training}, booktitle = {7th International Conference, MIAR 2016}, volume = {Medical Imaging and Augmented Reality - Volume 9805 of the series Lecture Notes in Computer Science }, year = {2016}, pages = {186-197}, publisher = {Springer International Publishing}, organization = {Springer International Publishing}, address = {Bern, Switzerland, August 24-26, 2016}, abstract = {

Palpation is an essential step of several open surgical procedures for locating arteries by arterial pulse detection. In this context, surgical simulation would ideally provide realistic haptic sensations to the operator. This paper presents a proof of concept implementation of tactile augmented reality for open-surgery training. The system is based on the integration of a wearable tactile device into an augmented physical simulator which allows the real time tracking of artery reproductions and the user finger and provides pulse feedback during palpation. Preliminary qualitative test showed a general consensus among surgeons regarding the realism of the arterial pulse feedback and the usefulness of tactile augmented reality in open-surgery simulators.

}, keywords = {Bioengineering}, isbn = {978-3-319-43774-3}, author = {S. Condino and R. Vigliaoro and M. Bianchi and Morelli, L and M. Ferrari and A. Bicchi and V. Ferrari} } @article {2513, title = {ADMET: ADipocyte METabolism mathematical model}, journal = {Computer methods in biomechanics and biomedical engineering}, volume = {18(13)}, year = {2015}, pages = {1386 -1391}, keywords = {Bioengineering}, author = {Micheloni, A. and G. Orsi and C. De Maria and G. Vozzi} } @conference {2593, title = {Arousal recognition system based on heartbeat dynamics during auditory elicitation}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, note = {

Published

}, pages = {6110{\textendash}6113}, publisher = {IEEE}, organization = {IEEE}, address = {Milano, ITA}, keywords = {Bioengineering}, doi = {10.1109/EMBC.2015.7319786}, author = {M. Nardelli and G. Valenza and A. Greco and A Lanata and E. P. Scilingo} } @book {3240, title = {Autonomic Nervous System Dynamics for Mood and Emotional-State Recognition [electronic resource]: Significant Advances in Data Acquisition, Signal Processing and Classification}, series = {Series in BioEngineering}, year = {2015}, publisher = {Springer}, organization = {Springer}, keywords = {Bioengineering}, author = {G. Valenza and E. P. Scilingo} } @article {2499, title = {Biomimicking of the Breast Tumor Microenvironment}, journal = {Current Molecular Biology Reports}, volume = {1 (2)}, year = {2015}, pages = {71-76}, keywords = {Bioengineering}, author = {M. Giussani and C. De Maria and M. Vasso and F. Montemurro and T. Triulzi and E. Tagliabue and C. Gelfi and G. Vozzi} } @conference {3250, title = {Brain dynamics during emotion elicitation in healthy subjects: An EEG study}, booktitle = {AEIT International Annual Conference (AEIT), 2015}, year = {2015}, pages = {1{\textendash}3}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and A. Greco and A. Lanat{\`a} and C. Gentili and D. Menicucci and Sebastiani, L. and A. Gemignani and E. P. Scilingo} } @article {2509, title = {CFD modelling of a mixing chamber for the realisation of functionally graded scaffolds}, journal = {Computers and Chemical Engineering}, year = {2015}, abstract = {

Biological tissues are characterised by spatially distributed gradients, intricately linked with functions. It widely accepted that ideal tissue engineered scaffolds should exhibit similar functional gradients to promote successful tissue regeneration. Focusing on bone, in previous work we proposed simple methods to obtain osteochondral functionally graded scaffolds (FGSs), starting from homogeneous suspensions of hydroxyapatite (HA) particles in gelatin solutions. With the main aim of developing an automated device to fabricate FGSs, this work is focused on designing a stirred tank to obtain homogeneous HA-gelatin suspensions. The HA particles transport within the gelatin solution was investigated through computational fluid dynamics (CFD) modelling. First, the steady-state flow field was solved for the continuous phase only. Then, it was used as a starting point for solving the multi-phase transient simulation. CFD results showed that the proposed tank geometry and setup allow for obtaining a homogeneous suspension of HA micro-particles within the gelatin solution.

}, keywords = {Bioengineering}, issn = {00981354}, doi = {10.1016/j.compchemeng.2015.08.021}, url = {http://www.sciencedirect.com/science/article/pii/S0098135415002823}, author = {G. Mattei and G. Vozzi} } @conference {3248, title = {Changes in instantaneous complex dynamics during exercise in Chronic Mountain Sickness}, booktitle = {Computing in Cardiology Conference (CinC), 2015}, year = {2015}, pages = {997{\textendash}1000}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and F. Faita and L. Pratali and N. Vanello and A Lanata and R. Barbieri and E. P. Scilingo} } @article {3237, title = {Characterization of Depressive States in Bipolar Patients using Wearable Textile Technology and Instantaneous Heart Rate Variability Assessment}, journal = {IEEE Journal of Biomedical and Health Informatics}, volume = {19}, year = {2015}, pages = {263{\textendash}274}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and C. Gentili and A Lanata and E. P. Scilingo and R. Barbieri} } @article {2501, title = {Combining Inkjet Printing and Sol-Gel chemistry for Making pH-Sensitive surfaces}, journal = {Current topics in medicinal chemistry}, volume = {15(3)}, year = {2015}, pages = {271-278}, keywords = {Bioengineering}, author = {G. Orsi and C. De Maria and F. Montemurro and Chauhan, V. and Aylott, J. and G. Vozzi} } @article {3238, title = {Complexity Index from a Personalized Wearable Monitoring System for Assessing Remission in Mental Health}, journal = {IEEE Journal of Biomedical and Health Informatics}, volume = {19}, year = {2015}, pages = {132{\textendash}139}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and M. Nardelli and C. Gentili and E. P. Scilingo} } @conference {2495, title = {Damasio{\textquoteright}s Somatic Marker for Social Robotics: Preliminary Implementation and Test}, booktitle = {Living Machines - The 4th International Conference on Biomimetic and Biohybrid Systems}, year = {2015}, pages = {316-328}, publisher = {Springer}, organization = {Springer}, address = {Barcelona, Spain, 28 - 31 July 2015}, keywords = {Bioengineering}, url = {http://link.springer.com/chapter/10.1007/978-3-319-22979-9_31$\#$page-1}, author = {Cominelli, L. and D. Mazzei and M. Pieroni and A. Zaraki and R. Garofalo and D. De Rossi} } @article {2510, title = {Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation}, journal = {Scientific Reports}, volume = {5}, year = {2015}, pages = {10778}, keywords = {Bioengineering}, issn = {2045-2322}, doi = {10.1038/srep10778}, url = {http://www.nature.com/doifinder/10.1038/srep10778}, author = {G. Mattei and Ferretti, C. and Tirella, A and A. Ahluwalia and Mattioli-Belmonte, M.} } @article {2498, title = {Design and Validation of an Open-Hardware Print-Head forBioprinting Application}, journal = {Procedia Engineering}, volume = {110}, year = {2015}, pages = {98-105}, keywords = {Bioengineering}, author = {C. De Maria and L. Ferrari and F. Montemurro and G. Vozzi and I. Guerrazzi and Boland, T. and G. Vozzi} } @conference {2596, title = {Electrodermal activity analysis during affective haptic elicitation}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, note = {

Published

}, pages = {5777{\textendash}5780}, publisher = {IEEE}, organization = {IEEE}, address = {Milano, ITA}, keywords = {Bioengineering}, doi = {10.1109/EMBC.2015.7319705}, author = {A. Greco and G. Valenza and M. Nardelli and M. Bianchi and A Lanata and E. P. Scilingo} } @conference {2592, title = {Electroencephalographic spectral correlates of caress-like affective haptic stimuli}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, note = {

Published

}, pages = {4733{\textendash}4736}, publisher = {IEEE}, organization = {IEEE}, address = {Milano, ITA}, keywords = {Bioengineering}, doi = {10.1109/EMBC.2015.7319451}, author = {G. Valenza and A. Greco and M. Nardelli and M. Bianchi and A Lanata and S. Rossi and E. P. Scilingo} } @conference {2718, title = {Evaluation of wearable KPF goniometers in knee flexion-extension measurement for daily-life applications}, booktitle = {Proceedings of Wireless EAI 4th International Conference on Mobile Communication and Healthcare (Mobihealth)}, year = {2015}, pages = {1-4}, publisher = {ICST (Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering}, organization = {ICST (Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering}, keywords = {Bioengineering}, doi = {10.4108/eai.14-10-2015.2261613}, url = {http://dl.acm.org/citation.cfm?id=2897477}, author = {F. Lorussi and N. Carbonaro and D. De Rossi and A. Tognetti} } @conference {2594, title = {Gender-specific velocity recognition of caress-like stimuli through nonlinear analysis of Heart Rate Variability}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, note = {

Published

}, pages = {298{\textendash}301}, publisher = {IEEE}, organization = {IEEE}, address = {Milano, ITA}, keywords = {Bioengineering}, doi = {10.1109/EMBC.2015.7318359}, author = {M. Nardelli and G. Valenza and M. Bianchi and A. Greco and A Lanata and A. Bicchi and E. P. Scilingo} } @article {2507, title = { HisTOOLogy: an open-source tool for quantitative analysis of histological sections }, journal = {Journal of Microscopy}, year = {2015}, month = {08/2015}, keywords = {Bioengineering}, doi = {10.1111/jmi.12292. }, author = {C. Magliaro and Tirella, A and G. Mattei and Pirone, A. and A. Ahluwalia} } @article {2263, title = {How the autonomic nervous system and driving style change with incremental stressing conditions during simulated driving}, journal = {IEEE Transactions on Intelligent Transportation Systems}, year = {2015}, pages = {1505 - 1517 }, keywords = {Bioengineering}, doi = {10.1109/TITS.2014.2365681}, author = {A Lanata and G. Valenza and A. Greco and C. Gentili and F. Bucchi and F. Frendo and E. P. Scilingo} } @article {2497, title = {Improving African Healthcare through Open Source Biomedical Engineering}, journal = {International Journal On Advances in Life Sciences}, year = {2015}, month = {01/2015}, keywords = {Bioengineering}, author = {C. De Maria and D. Mazzei and A. Ahluwalia} } @inbook {2502, title = {Indirect Rapid Prototyping for Tissue Engineering}, booktitle = {Essential of 3D Biofabrication and Translation}, year = {2015}, publisher = {Elsevier}, organization = {Elsevier}, keywords = {Bioengineering}, issn = {978-0-12-800972-7}, author = {C. De Maria and De Acutis, A and G. Vozzi} } @conference {3251, title = {Instantaneous Bispectral Analysis of Heartbeat Dynamics for the Assessment of Major Depression}, booktitle = {Computing in Cardiology Conference (CinC)}, year = {2015}, keywords = {Bioengineering}, author = {R. G. Garcia and G. Valenza and C. A. Tomaz and R. Barbieri} } @conference {3245, title = {Instantaneous transfer entropy for the study of cardio-respiratory dynamics}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, pages = {7885{\textendash}7888}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and L. Faes and L. Citi and Orini, M. and R. Barbieri} } @conference {3247, title = {Lower instantaneous entropy of heartbeat dynamics during seizures in untreated temporal lobe epilepsy}, booktitle = {Computing in Cardiology Conference (CinC), 2015}, year = {2015}, pages = {1037{\textendash}1040}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {Barbieri, R. and G. Valenza and L. Citi and F. Placidi and F. Izzi and M. Albanese and M. Marciani and M. Guerrisi and A. Romigi and N. Toschi} } @article {2500, title = {Magnetic-Driven Pointing System: a Feasibility Study}, journal = {Sensors Journal}, volume = {15 (2)}, year = {2015}, month = {02/2015}, pages = {703 - 714}, keywords = {Bioengineering}, author = {G. Russo and C. De Maria and Cerulli, G. and G. Vozzi} } @article {2716, title = {Music, clicks, and their imaginations favor differently the event-based timing component for rhythmic movements}, journal = {EXPERIMENTAL BRAIN RESEARCH}, volume = {233}, year = {2015}, pages = {1945{\textendash}1961}, keywords = {Bioengineering}, issn = {0014-4819}, doi = {10.1007/s00221-015-4267-z}, url = {http://dx.medra.org/10.1007/s00221-015-4267-z}, author = {Bravi, R. and E. Quarta and Del Tongo, C. and N. Carbonaro and A. Tognetti and Minciacchi, D.} } @article {2508, title = {The nano-epsilon dot method for strain rate viscoelastic characterisation of soft biomaterials by spherical nano-indentation}, journal = {Journal of the Mechanical Behavior of Biomedical Materials}, volume = {50}, year = {2015}, pages = {150{\textendash}159}, keywords = {Bioengineering}, issn = {17516161}, doi = {10.1016/j.jmbbm.2015.06.015}, url = {http://linkinghub.elsevier.com/retrieve/pii/S1751616115002088}, author = {G. Mattei and G. Gruca and Rijnveld, N. and A. Ahluwalia} } @article {2511, title = {Nano-in-Micro Self-Reporting Hydrogel Constructs}, journal = {Journal of Biomedical Nanotechnology}, volume = {11}, year = {2015}, pages = {1451{\textendash}1460}, keywords = {Bioengineering}, issn = {15507033}, doi = {10.1166/jbn.2015.2085}, url = {http://openurl.ingenta.com/content/xref?genre=article\&issn=1550-7033\&volume=11\&issue=8\&spage=1451}, author = {Tirella, A and La Marca, M and Brace, L.A. and G. Mattei and Aylott, J. and A. Ahluwalia} } @article {2717, title = {Neuro-fuzzy physiological computing to assess stress levels in virtual reality therapy}, journal = {INTERACTING WITH COMPUTERS}, volume = {27}, year = {2015}, pages = {521{\textendash}533}, keywords = {Bioengineering}, issn = {0953-5438}, doi = {10.1093/iwc/iwv010}, url = {http://dx.medra.org/10.1093/iwc/iwv010}, author = {Tartarisco, G. and N. Carbonaro and A. Tonacci and G. M. Bernava and A. Arnao and G. Crifaci and P. Cipresso and G. Riva and A. Gaggioli and D. De Rossi and A. Tognetti and G. Pioggia} } @article {3239, title = {Nonlinear digital signal processing in mental health: characterization of major depression using instantaneous entropy measures of heartbeat dynamics}, journal = {Frontiers in physiology}, volume = {6}, year = {2015}, keywords = {Bioengineering}, author = {G. Valenza and R. G. Garcia and L. Citi and E. P. Scilingo and C. A. Tomaz and R. Barbieri} } @article {3242, title = {A novel algorithm for movement artifact removal in ECG signals acquired from wearable systems applied to horses}, journal = {PloS one}, volume = {10}, year = {2015}, pages = {e0140783}, keywords = {Bioengineering}, author = {A Lanata and Guidi, A. and P. Baragli and G. Valenza and E. P. Scilingo} } @conference {2504, title = {Open Biomedical Engineering Education in Africa}, booktitle = {The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)}, year = {2015}, publisher = {IEEE}, organization = {IEEE}, address = { Milan, Italy, 25-29 August 2015}, keywords = {Bioengineering}, author = {A. Ahluwalia and D. Atwine and C. De Maria and C. Ibingira and E. Kipkorir and F. Kiros and J. Madete and D. Mazzei and E. Molyneux and K. Moonga and M. Moshi and M. Nzomo and V. Oduol and J. Okuonzi} } @conference {2512, title = {P2SF: Physically-based Point Spread Function for digital image processing}, booktitle = {Imaging Systems and Applications}, year = {2015}, pages = {IT3A{\textendash}5}, publisher = {Optical Society of America}, organization = {Optical Society of America}, keywords = {Bioengineering}, author = {M. Pieroni and B. Wandell and P. Catrysse and D. De Rossi} } @article {2505, title = {Parvalbumin expression in the claustrum of human dog. An immunohistochemical and topographical study with comparative notes of the structure of the nucleus}, journal = {Journal of chemical neuroanatomy}, volume = {64-65}, year = {2015}, month = {03/2015}, pages = {33-42}, keywords = {Bioengineering}, doi = {10.1016/j.jchemneu.2015.02.004}, url = {http://www.sciencedirect.com/science/article/pii/S0891061815000149}, author = {Pirone, A. and C. Magliaro and Giannessi, E. and A. Ahluwalia} } @conference {3249, title = {Predicting mood changes in bipolar disorder through heartbeat nonlinear dynamics: A preliminary study}, booktitle = {Computing in Cardiology Conference (CinC), 2015}, year = {2015}, pages = {801{\textendash}804}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and M. Nardelli and A. Lanat{\`a} and C. Gentili and G. Bertschy and E. P. Scilingo} } @article {2506, title = {Profile analysis of hepatic porcine and murine brain tissue slices obtained with a vibratome}, journal = {PeerJ}, volume = {3:e932}, year = {2015}, month = {04/2015}, keywords = {Bioengineering}, doi = {10.7717/peerj.932}, url = {https://peerj.com/articles/932/}, author = {G. Mattei and I. Cristiani and C. Magliaro and A. Ahluwalia} } @article {2514, title = {Realisation and characterization of conductive hollow fibers for neuronal tissue engineering}, journal = {Journal of Biomedical Materials Research - Part B Applied Biomaterials}, volume = {103}, year = {2015}, pages = {1107-1119}, keywords = {Bioengineering}, author = {Gattazzo, F. and C. De Maria and Whulanza, Y. and Taverni, G. and A. Ahluwalia and G. Vozzi} } @conference {3243, title = {Removing movement artifacts from equine ECG recordings acquired with textile electrodes}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, pages = {1955{\textendash}1958}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {A Lanata and Guidi, A. and P. Baragli and R. Paradiso and G. Valenza and E. P. Scilingo} } @article {3244, title = {Robust Head Mounted Wearable Eye Tracking System for Dynamical Calibration}, journal = {Journal of Eye Movement Research}, volume = {8}, year = {2015}, pages = {1{\textendash}15}, keywords = {Bioengineering}, author = {A Lanata and A. Greco and G. Valenza and E. P. Scilingo} } @conference {2595, title = {On the tridimensional estimation of the gaze point by a stereoscopic wearable eye tracker}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE}, year = {2015}, note = {

Published

}, pages = {2283{\textendash}2286}, publisher = {IEEE}, organization = {IEEE}, address = {Milano, ITA}, keywords = {Bioengineering}, doi = {10.1109/EMBC.2015.7318848}, author = {A Lanata and A. Greco and G. Valenza and E. P. Scilingo} } @inbook {2503, title = {Utilizzo di Phantom in oftalmologia}, booktitle = {Metodiche alternative alla sperimentazione animale}, volume = {34}, year = {2015}, publisher = {P{\`a}tron Editore}, organization = {P{\`a}tron Editore}, address = {Bologna}, keywords = {Bioengineering}, issn = {9788855533157}, author = {G. Vozzi and C. De Maria and F. Montemurro} } @article {2715, title = {Wearable goniometer and accelerometer sensory fusion for knee joint angle measurement in daily-life}, journal = {SENSORS}, volume = {15}, year = {2015}, pages = {28435{\textendash}28455}, keywords = {Bioengineering}, issn = {1424-8220}, doi = {10.3390/s151128435}, url = {http://dx.medra.org/10.3390/s151128435}, author = {A. Tognetti and F. Lorussi and N. Carbonaro and D. De Rossi} } @article {2191, title = {ADMET: ADipocyte METabolism mathematical model}, journal = {Computer methods in biomechanics and biomedical engineering}, year = {2014}, pages = {1{\textendash}6}, keywords = {Bioengineering}, author = {Micheloni, A. and G. Orsi and C. De Maria and G. Vozzi} } @conference {2342, title = {Assessment of Dynamic Autonomic Changes with Posture using Instantaneous Entropy Measures}, booktitle = {Computers in Cardiology}, volume = { 41}, year = {2014}, note = {

Winner of a Mortara Fellowship

}, pages = {489-492}, address = {Cambridge (MA, USA)}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and E. P. Scilingo and R. Barbieri} } @article {2192, title = {An Autologously Generated Platelet-Rich Plasma Suturable Membrane May Enhance Peripheral Nerve Regeneration after Neurorraphy in an Acute Injury Model of Sciatic Nerve Neurotmesis}, journal = {Journal of reconstructive microsurgery}, year = {2014}, keywords = {Bioengineering}, author = {Giannessi, E. and Coli, A. and Stornelli, M. R. and Miragliotta, V. and Pirone, A. and Lenzi, C. and Burchielli, S. and G. Vozzi and C. De Maria and Giorgetti, M.} } @conference {2278, title = {Autonomous bioreactor modules for disease models and detection of systemic toxicity}, booktitle = {ALTEX Proceedings}, year = {2014}, pages = {43}, address = {Prague, Czech Republic}, abstract = {

Advanced systems based on bioreactors and scaffolds are an essential step towards the development of more predictive and ethical alternatives to animal experiments. Size, modularity, automation, monitoring and essential design are crucial because these elements will ease the transition from old technology and accelerate their acceptance into mainstream research. Based on these requirements, the interconnected transparent sensorised {\^a}{\texteuro}{\oe}lego{\^a}{\texteuro} bioreactors designed in our labs have been used to generate physiologically relevant disease and toxicity models which recapitulate systemic responses impossible to observe in standard cell cultures. The disease model is an interconnected bioreactor circuit with i) adipose tissue in 3D in 3 different concentrations representing normo-weight, over weight and obese body mass indices, ii) human hepatocytes on porous collagen scaffolds and iii) monolayers of human endothelial cells. High adiposity and elevated glucose levels induce systemic and endothelial inflammation in the circuit, as observed in overweight and diabetic humans (Iori et al., 2012). Using similar technology a three-tissue circuit for monitoring the absorption, distribution, metabolism and toxicity of nanoparticles was developed in the context of the EU project InLiveTox (Ucciferri et al., 2014). The results were strikingly similar to those observed in animal experiments demonstrating that the dynamic 3D in-vitro models are ethical, meaningful and economically viable replacements.

}, keywords = {Bioengineering}, author = {A. Ahluwalia and S. Giusti and Sbrana, T. and M. Wilkinson and A. Misto and Lehr, C.-M. and M. Liley}, editor = {S. Horst and D. J{\'\i}rov{\'a}} } @article {2145, title = {Characterization of Depressive States in Bipolar Patients using Wearable Textile Technology and Instantaneous Heart Rate Variability Assessment}, journal = {IEEE Journal of Biomedical and Health Informatics}, year = {2014}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and C. Gentili and A Lanata and E. P. Scilingo and R. Barbieri} } @article {1785, title = {CREPE: mathematical model for CRosstalking of Endothelial cells and hePatocytE metabolism}, journal = {IEEE Transactions of Biomedical Engineeirng}, volume = {61}, year = {2014}, month = {01/2014}, pages = {224 - 230}, keywords = {Bioengineering}, doi = { 10.1109/TBME.2013.2272942}, author = {Valvano, G and G. Orsi and M. A. Guzzardi and Vozzi, F. and G. Vozzi} } @article {2276, title = {Design Criteria for Generating Physiologically Relevant In Vitro Models in Bioreactors}, journal = {Processes}, volume = {2}, year = {2014}, pages = {548{\textendash}569}, abstract = {

In this paper, we discuss the basic design requirements for the development of physiologically meaningful in vitro systems comprising cells, scaffolds and bioreactors, through a bottom up approach. Very simple micro- and milli-fluidic geometries are first used to illustrate the concepts, followed by a real device case-study. At each step, the fluidic and mass transport parameters in biological tissue design are considered, starting from basic questions such as the minimum number of cells and cell density required to represent a physiological system and the conditions necessary to ensure an adequate nutrient supply to tissues. At the next level, we consider the use of three-dimensional scaffolds, which are employed both for regenerative medicine applications and for the study of cells in environments which better recapitulate the physiological milieu. Here, the driving need is the rate of oxygen supply which must be maintained at an appropriate level to ensure cell viability throughout the thickness of a scaffold. Scaffold and bioreactor design are both critical in defining the oxygen profile in a cell construct and are considered together. We also discuss the oxygen-shear stress trade-off by considering the levels of mechanical stress required for hepatocytes, which are the limiting cell type in a multi-organ model. Similar considerations are also made for glucose consumption in cell constructs. Finally, the allometric approach for generating multi-tissue systemic models using bioreactors is described.

}, keywords = {Bioengineering}, issn = {2227-9717}, doi = {10.3390/pr2030548}, url = {http://www.mdpi.com/2227-9717/2/3/548/}, author = {G. Mattei and S. Giusti and A. Ahluwalia} } @article {2203, title = {Development of a novel Micro-Ablation System to realise micrometric and well-defined hydrogel structures for Tissue Engineering applications}, journal = {Rapid Prototyping Journal}, volume = {20}, year = {2014}, keywords = {Bioengineering}, author = {C. De Maria and Grassi, L. and Vozzi, F. and A. Ahluwalia and G. Vozzi and Campbell, R. I.} } @article {2340, title = {Estimation of Instantaneous Complex Dynamics through Lyapunov Exponents: A Study on Heartbeat Dynamics}, journal = {PLoS One}, volume = {9}, year = {2014}, pages = {e105622}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and R. Barbieri} } @conference {2273, title = {Fluid dynamics in porous scaffolds stimulated with cyclic squeeze pressure in the S2PR bioreactor}, booktitle = {Gruppo Nazionale Bioingegneria IV Congresso}, year = {2014}, address = {Pavia, 25-27 June}, abstract = {

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on the cells and recreate a physiological environment for cardiomyocytes cultures. This work is focused on an innovative Sensorized Squeeze PRessure (S2PR) bioreactor, able to apply a periodic contactless hydrodynamic pressures on 3D porous constructs. The fluid-dynamic environment inside the bioreactor was fully characterized using computational models, focusing on the pressures and fluid velocity profiles generated in the porous scaffold during the cyclic stimulation.

}, keywords = {Bioengineering}, author = {M. Ferroni and S. Giusti and G. Spatafora and F. Boschetti and A. Ahluwalia} } @conference {2277, title = {Fluid dynamics in porous scaffolds stimulated with cyclic squeeze pressure in the S2PR bioreactor}, booktitle = {Proceedings of ICMMB2014}, year = {2014}, pages = {363{\textendash}68}, keywords = {Bioengineering}, doi = {10.6092/unibo/amsacta/4085. In: Proceedings ICMMB A cura di: Zannoli, Romani ; Corazza, Ivan ; Stagni, Rita.}, url = {http://amsacta.unibo.it/4085/1/Proceedings{\.I}CMMB2014.pdf}, author = {M. Ferroni and S. Giusti and G. Spatafora and F. Boschetti and A. Ahluwalia} } @article {2240, title = {For every thing there is a season and a time ? the construction of a humanoid. A tribute to Vincenzo Tagliasco}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {2}, year = {2014}, abstract = {

"There is a time to be born, and a time to die; a time to break down, and a time to build up; a time to weep, and a time to laugh; a time to keep silence, and a time to speak" (Ecclesiastes 3, 2?7). There was a time when automata were designed like clocks. Androids will have the time of their creators, the state of the art in technology, a wealth of experience to draw from, as well as the capacity to carry out actions as being endowed with meaning. The machine will undergo a long period of nurturing, from which it will learn to shape some sort of identity.

}, keywords = {Bioengineering}, doi = {10.3389/fbioe.2014.00019}, url = {http://journal.frontiersin.org/Journal/10.3389/fbioe.2014.00019/abstract}, author = {D. De Rossi and A. D{\textquoteright}Ursi} } @article {2196, title = {In vivo assessment of printed microvasculature in a bilayer skin graft to treat full-thickness wounds}, journal = {Tissue Engineering Part A}, year = {2014}, keywords = {Bioengineering}, author = {Yanez, M. and Rincon, J. and Dones, A. and C. De Maria and Gonzales, R. and Boland, T.} } @conference {2197, title = {In-silico model of cell metabolism in dynamic cell culture system}, booktitle = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, year = {2014}, pages = {487{\textendash}488}, publisher = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, keywords = {Bioengineering}, author = {Andreoni, C. and G. Orsi and C. De Maria and F. Montemurro and G. Vozzi} } @conference {2201, title = {Keratin based hydrogels for tissue engineering and regenerative medicine}, booktitle = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, year = {2014}, pages = {357{\textendash}358}, publisher = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, keywords = {Bioengineering}, author = {F. Montemurro and Gattazzo, F. and C. De Maria and G. Vozzi} } @conference {2344, title = {Maximal-Radius Multiscale Entropy of Cardiovascular Variability: A Promising Biomarker of Pathological Mood States in Bipolar Disorders}, booktitle = {36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, year = {2014}, keywords = {Bioengineering}, author = {G. Valenza and M. Nardelli and G. Bertschy and A Lanata and R. Barbieri and E. P. Scilingo} } @article {2032, title = {Modulation of isochronous movements in a flexible environment: links between motion and auditory experience}, journal = {Experimental Brain Research}, volume = {232}, year = {2014}, month = {06/2014}, pages = {1663 - 1675}, keywords = {Bioengineering}, doi = {10.1007/s00221-014-3845-9}, author = {Bravi, R. and Del Tongo, C. and Cohen, E. J. and Dalle Mura, G. and A. Tognetti and Minciacchi, D.} } @conference {2198, title = {Multimaterial and multiscale biofabrication for smart scaffolds}, booktitle = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, year = {2014}, pages = {470{\textendash}470}, publisher = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, keywords = {Bioengineering}, author = {C. De Maria and Carrabba, M. and G. Criscenti and G. Orsi and F. Montemurro and G. Vozzi} } @conference {2280, title = {Multi-organ-on-plate system for in-vitro studies of intestinal drug absorption and hepatotoxicity}, booktitle = {ESTIV 2014}, year = {2014}, pages = {107}, address = {Egmond aan Zee, The Netherlands}, abstract = {

More meaningful in-vitro models which simulate the physiological conditions of native tissue are becoming essential in the pharmaceutical field, for early and rapid screening of drug candidates. Here, we describe a multi-organ-on-plate system based on single and double flow mini bioreactor modules for dynamic in-vitro studies of intestinal drug absorption, drug metabolism and more relevant toxicity studies. The double flow module for membrane culture was firstly characterized using computational fluid dynamic models and measurements of pressure gradients, in order to indentify the optimal flow rates for maximizing the passage of solutes through the membrane. Then, cell culture experiments were performed with fully differentiated Caco-2 cells seeded on the semi-permeable membrane as a dynamic model of the intestinal epithelium, connected to a single flow chamber with metabolically competent human upcyte{\^A}{\textregistered} hepatocytes (Medicyte GmbH, Germany) seeded on a 3D collagen cryogel. First we assessed the role of flow in modulating the passage of compounds across the epithelial barrier. Then toxicity tests were performed by administering different concentrations of hepatotoxic compounds (i.e. Diclofenac, Nimesulide, industrial nanoparticles) in the apical compartment of the MB, compared the data with cell cultures in transwells. Our results show: i) the presence of flow significantly increases translocation of all molecules tested across the membrane, ii) flow conditioned Caco-2 cells are more permeable to small hydrophilic compounds, despite having high TEER values iii) although they display higher levels of phenotypic markers (tight junctions, albumin expression etc), cells in the system are more susceptible to drug induced toxicity. In conclusion, the multi-organ-on-plate system predicts drug adsorption and toxicity better than traditional cell cultures and could be used to reduce, refine and eventually replace animal tests.

}, keywords = {Bioengineering}, author = {S. Giusti and Sbrana, T. and D. Giacopelli and V. Di Patria and A. Ahluwalia} } @conference {2199, title = {Nanoparticles doped sol-gel ink for inkjet printers}, booktitle = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, year = {2014}, pages = {197{\textendash}198}, publisher = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, keywords = {Bioengineering}, author = {G. Orsi and C. De Maria and F. Montemurro and Chauhan, V. and Aylott, J. and G. Vozzi} } @conference {2279, title = {The need of innovative technologies for new 3D relevant in-vitro models and the answer of Ivtech}, booktitle = {ALTEX Proceedings}, year = {2014}, pages = {45{\textendash}6}, address = {Prague, Czech Republic}, abstract = {

New relevant in-vitro models are priorities in pharmaco-toxicology, cosmetic and food research to reduce the animal tests. Therefore, invivo models show ethical issues, are not time and cost effective and are progressively showing scientific limitations: for instance they fail in detection of pathogens that are species specific (Mazzoleni et al., 2009). The search of more relevant pre-clinical models forced the researcher to move from 2D to 3D in-vitro models in order to maintain the phenotype of cells (Lovit et al., 2013; Mattei et al., 2014). Even if the significant progress in material science, the metabolic requirement of 3D tissues is higher than a 2D culture and the scaffold is a limitation in nutrients transport. Dynamic cell culture chambers are then required to assure the gas/nutrient supply, waste elimination, mechanical stimulation of cells, study of cross talk between different tissues and real time monitoring of cells. Nowadays the only systems that meet all these specifications are the Ivtech technologies. Ivtech is an innovative Italian start-up that grows up to solve the needs of in-vitro experts, offering and customizing several type of transparent, dynamic and modular cell culture systems, organizing workshops and training. The goal is to expand the 3D approach and permits a significant evolution towards highly relevant in-vitro models.

}, keywords = {Bioengineering}, author = {Sbrana, T. and G. Mattei and S. Giusti and A. Ahluwalia}, editor = {J. Dagmar and S. Horst} } @article {2194, title = {A new 3D concentration gradient maker and its application in building hydrogels with a 3D stiffness gradient}, journal = {Journal of Tissue Engineering and Regenerative Medicine}, year = {2014}, keywords = {Bioengineering}, author = {G. Orsi and Fagnano, M. and C. De Maria and F. Montemurro and G. Vozzi} } @article {2193, title = {New eye phantom for ophthalmic surgery.}, journal = {Journal of biomedical optics}, volume = {19}, year = {2014}, pages = {68001}, keywords = {Bioengineering}, author = {Fogli, G. and G. Orsi and C. De Maria and F. Montemurro and Palla, M. and Rizzo, S. and G. Vozzi} } @conference {2200, title = {A novel concentration gradient bioreactor by PMMA laser micromachining}, booktitle = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, year = {2014}, pages = {482{\textendash}482}, publisher = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, keywords = {Bioengineering}, author = {G. Orsi and C. De Maria and F. Montemurro and G. Vozzi} } @article {2274, title = {A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers}, journal = {Biotechnology journal}, year = {2014}, abstract = {

Permeability studies across epithelial barriers are of primary importance in drug delivery as well as in toxicology. However, traditional in vitro models do not adequately mimic the dynamic environment of physiological barriers. Here, we describe a novel two-chamber modular bioreactor for dynamic in vitro studies of epithelial cells. The fluid dynamic environment of the bioreactor was characterized using computational fluid dynamic models and measurements of pressure gradients for different combinations of flow rates in the apical and basal chambers. Cell culture experiments were then performed with fully differentiated Caco-2 cells as a model of the intestinal epithelium, comparing the effect of media flow applied in the bioreactor with traditional static transwells. The flow increases barrier integrity and tight junction expression of Caco-2 cells with respect to the static controls. Fluorescein permeability increased threefold in the dynamic system, indicating that the stimulus induced by flow increases transport across the barrier, closely mimicking the in vivo situation. The results are of interest for studying the influence of mechanical stimuli on cells, and underline the importance of developing more physiologically relevant in vitro tissue models. The bioreactor can be used to study drug delivery, chemical, or nanomaterial toxicity and to engineer barrier tissues.

}, keywords = {Bioengineering}, issn = {1860-7314}, doi = {10.1002/biot.201400004}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24756869}, author = {S. Giusti and Sbrana, T. and La Marca, M and V. Di Patria and V. Martinucci and Tirella, A and C. Domenici and A. Ahluwalia} } @conference {2190, title = {Open Source Biomedical Engineering for Sustainability in African Healthcare: Combining Academic Excellence with Innovation}, booktitle = {ICDS 2014, The Eighth International Conference on Digital Society}, year = {2014}, pages = {48{\textendash}53}, keywords = {Bioengineering}, author = {C. De Maria and D. Mazzei and A. Ahluwalia} } @article {2341, title = {Point-Process Nonlinear Autonomic Assessment of Depressive States in Bipolar Patients}, journal = {Methods of Information in Medicine}, volume = {53}, year = {2014}, note = {

invited

}, pages = {296{\textendash}302}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and C. Gentili and A Lanata and E. P. Scilingo and R. Barbieri} } @article {2202, title = {Realisation and characterization of conductive hollow fibers for neuronal tissue engineering}, journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials}, year = {2014}, keywords = {Bioengineering}, author = {Gattazzo, F. and C. De Maria and Whulanza, Y. and Taverni, G. and A. Ahluwalia and G. Vozzi} } @conference {2187, title = {Recognition and Expression of Emotions by a Symbiotic Android Head}, booktitle = {IEEE-RAS International Conference on Humanoid Robots (HUMANOIDS 2014)}, year = {2014}, pages = {134 - 139 }, publisher = {IEEE}, organization = {IEEE}, address = {Madrid, Spain, November 18 - 20}, keywords = {Bioengineering, Robotics}, doi = {10.1109/HUMANOIDS.2014.7041349}, author = {D. Mazzei and A. Zaraki and Lazzeri, N. and D. De Rossi} } @article {2149, title = {Revealing Real-Time Emotional Responses: a Personalized Assessment based on Heartbeat Dynamics}, journal = {Nature Scientific Reports}, volume = {4}, year = {2014}, pages = {1{\textendash}13}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and A Lanata and E. P. Scilingo and R. Barbieri} } @conference {2188, title = {An RGB-D Based Social Behavior Interpretation System for a Humanoid Social Robot}, booktitle = {IEEE-RSI International Conference on Robotics and Mechatronics 2014 }, year = {2014}, pages = {185 - 190}, publisher = {IEEE}, organization = {IEEE}, address = {Tehran, Iran, October 15-17}, keywords = {Bioengineering, Robotics}, doi = {10.1109/ICRoM.2014.6990898}, author = {A. Zaraki and Giuliani, M. and Dehkordi, M. B. and D. Mazzei and D{\textquoteright}Ursi, A. and D. De Rossi} } @conference {2275, title = {Sensorized Squeeze Pressure Bioreactor For mechanical modulation of cardiomyocyte phenotype}, booktitle = {Journal of tissue engineering and regenerative medicine}, volume = {8 Suppl 1}, year = {2014}, pages = {67{\textendash}8}, keywords = {Bioengineering}, doi = {10.1002/term.1943}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24912686}, author = {S. Giusti and Vozzi, F. and F. Pagliari and Tirella, A and D. Mazzei and Cabiati, M and S. del Ry and A. Ahluwalia} } @article {2204, title = {Smart Sensing Scaffolds}, journal = {Smart Membranes and Sensors: Synthesis, Characterization, and Applications}, year = {2014}, pages = {337}, keywords = {Bioengineering}, author = {C. De Maria and Whulanza, Y. and G. Vozzi and A. Ahluwalia} } @article {2290, title = {Sphyga: a multiparameter open source tool for fabricating smart and tunable hydrogel microbeads}, journal = {Biofabrication}, volume = {6}, year = {2014}, keywords = {Bioengineering}, doi = {10.1088/1758-5082/6/2/025009}, author = {Tirella, A and C. Magliaro and M. Penta and M. Troncone and Pimentel, R and A. Ahluwalia} } @conference {2343, title = {Tracking Instantaneous Entropy in Heartbeat Dynamics through Inhomogeneous Point-Process Nonlinear Models}, booktitle = {36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, year = {2014}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and E. P. Scilingo and R. Barbieri} } @article {2177, title = {Tuning of the freezing and melting points of [Hmim][NO3] by the addition of water and nitrate salts }, journal = {RSC Advances}, volume = {4}, year = {2014}, pages = {40407 - 40413}, keywords = {Bioengineering}, doi = {10.1039/c4ra06290f}, author = {Di Francesco, F. and Ferrari, F. and Moni, L. and Melai, B. and Bernazzania, L. and Chiappe, C.} } @article {2143, title = {Wearable Monitoring for Mood Recognition in Bipolar Disorder based on History-Dependent Long-Term Heart Rate Variability Analysis}, journal = {IEEE Journal of Biomedical and Health Informatics}, year = {2014}, keywords = {Bioengineering}, author = {G. Valenza and M. Nardelli and A Lanata and C. Gentili and G. Bertschy and R. Paradiso and E. P. Scilingo} } @article {2241, title = {Wearable Wireless Tactile Display for Virtual Interactions with Soft Bodies}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {2}, year = {2014}, abstract = {

We describe here a wearable, wireless, compact, and lightweight tactile display, able to mechanically stimulate the fingertip of users, so as to simulate contact with soft bodies in virtual environments. The device was based on dielectric elastomer actuators, as high-performance electromechanically active polymers. The actuator was arranged at the user{\textquoteright}s fingertip, integrated within a plastic case, which also hosted a compact high-voltage circuitry. A custom-made wireless control unit was arranged on the forearm and connected to the display via low-voltage leads. We present the structure of the device and a characterization of it, in terms of electromechanical response and stress relaxation. Furthermore, we present results of a psychophysical test aimed at assessing the ability of the system to generate different levels of force that can be perceived by users.

}, keywords = {Bioengineering}, doi = {10.3389/fbioe.2014.00031}, url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150388/}, author = {G. Frediani and D. Mazzei and D. De Rossi and F. Carpi} } @conference {1812, title = {Advanced Interfaces to Stem the Data Deluge in Mixed Reality: Placing Human (un)consciuosness in the Loop}, booktitle = {ACM SIGGRAPH 2013}, year = {2013}, address = {New York, NY, USA}, keywords = {Bioengineering}, url = {10.1145/2503385.2503460}, author = {A. Betella and E. Mart{\`\i}nez and R. Zucca and X. D. Arsiwalla and P Omedas and S. Wierenga and A. Mura and J. Wagner and F. Lingenfelser and E. Andr{\'e} and D. Mazzei and A. Tognetti and A Lanata and D. De Rossi and P. F. M. J. Verschure} } @article {2148, title = {Advanced Technology Meets Mental Health: How smartphones, textile electronics, and signal processing can serve mental health monitoring, diagnosis, and treatment.}, journal = {IEEE pulse}, volume = {5}, year = {2013}, pages = {56{\textendash}59}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and R. Paradiso and E. P. Scilingo} } @article {1492, title = {Bone scaffolds with homogeneous and discrete gradient mechanical properties}, journal = {MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS}, volume = {1}, year = {2013}, pages = {28{\textendash}36}, keywords = {Bioengineering}, issn = {0928-4931}, author = {Jelen, C. and G. Mattei and F. Montemurro and C. De Maria and Mattioli-Belmonte, M. and G. Vozzi} } @article {1779, title = {Characterization of 3-Iodothyronamine In Vitro Dynamics by Mathematical Modeling}, journal = {Cell Biochem Biophys}, year = {2013}, keywords = {Bioengineering}, doi = {10.1007/s12013-013-9680-y}, author = {G. Orsi and S. Ghelardoni and A. Saba and R. Zucca and G. Vozzi} } @article {1781, title = {Collagen VI regulates satellite cell self-renewal and muscle regeneration}, journal = {Nat Commun}, volume = {4}, year = {2013}, keywords = {Bioengineering}, doi = {10.1038/ncomms2964}, author = {Urciuolo, A and M. Quarta and V. Morbidoni and Gattazzo, F and S. Molon and P. Grumati and F. Montemurro and F. S. Tedesco and B. Blaauw and G. Cossu and G. Vozzi and T. A. Rando and Bonaldo, P} } @article {1780, title = {Collagen-gelatin-genipin-hydroxyapatite composite scaffolds colonized by human primary osteoblasts are suitable for bone tissue engineering applications: In vitro evidences}, journal = {J Biomed Mater Res A}, year = {2013}, month = {06/2013}, keywords = {Bioengineering}, author = {G. Vozzi and C. Corallo and S. Carta and M. Fortina and Gattazzo, F and M. Galletti and N. Giordano} } @article {1786, title = {Collagen-gelatin-genipin-hydroxyapatite composite scaffolds colonized by human primary osteoblasts are suitable for bone tissue engineering applications: In vitro evidences}, journal = {Journal of Biomedical Materials Research Part A}, year = {2013}, keywords = {Bioengineering}, doi = {10.1002/jbm.a.34823}, author = {G. Vozzi and C. Corallo and S. Carta and M. Fortina and Gattazzo, F and M. Galletti and N. Giordano} } @inbook {1787, title = {Da scaffold a tessuti: progettazione, realizzazione e caratterizzazione di architetture 3D per la medicina rigenerativa }, booktitle = {Approccio Integrato per la medicina rigenerativa - book of XXXII School of Bioengineering}, year = {2013}, keywords = {Bioengineering}, author = {Tirella, A and C. De Maria and G. Vozzi and A. Ahluwalia} } @article {1778, title = {Electrical and Mechanical Characterisation of single wall carbon nanotubes based composites for tissue engineering applications}, journal = {Journal of nanoscience and nanotechnology}, year = {2013}, month = {01/2013}, pages = {188 - 197}, keywords = {Bioengineering}, author = {Whulanza, Y and L. Vannozzi and Vomero, M. and A. Ahluwalia and G. Vozzi} } @article {2134, title = {Eye gaze patterns in emotional pictures}, journal = {Journal of Ambient Intelligence and Humanized Computing}, volume = {4}, year = {2013}, pages = {705{\textendash}715}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and E. P. Scilingo} } @conference {1798, title = {Gelatin-Hydroxyapatite hydrogels to investigate periosteal derived progenitor cells (PDPCs) response for tissue engineering applications}, booktitle = {Advanced Cell Culture}, year = {2013}, address = {Liverpool, UK}, keywords = {Bioengineering}, author = {G. Mattei and Tirella, A and Mattioli-Belmonte, M. and Ferretti, C and A. Ahluwalia} } @article {1809, title = {Grand Challenges in Bionics}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {1}, year = {2013}, keywords = {Bioengineering}, doi = {10.3389/fbioe.2013.00003}, author = {D. De Rossi and M. Pieroni} } @article {2138, title = {Improving emotion recognition systems by embedding cardiorespiratory coupling}, journal = {Physiological Measurement}, volume = {34}, year = {2013}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and E. P. Scilingo} } @article {1791, title = {In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response}, journal = {Nanotoxicology}, year = {2013}, abstract = {

Abstract After passage through biological barriers, nanomaterials inevitably end up in contact with the vascular endothelium and physiological flow, and can induce cardiovascular damage. In this study the toxicity and sublethal effects of 6 nanoparticles, including 4 of industrial and biomedical importance, on human endothelial cells was investigated using different in vitro assays. The results show that all the particles investigated induce some level of damage to the cells and that silver particles were most toxic, followed by titanium dioxide. Furthermore endothelial cells were shown to be more susceptible when exposed to silver nanoparticles under flow conditions in a bioreactor. The study underlines that although simple in vitro tests are useful to screen compounds and to identify the type of effect induced on cells, they may not be sufficient to define safe exposure limits. Therefore, once initial toxicity screening has been conducted on nanomaterials, it is necessary to develop more physiologically relevant in vitro models to better understand how nanomaterials can impact on human health.

}, keywords = {Bioengineering}, issn = {1743-5404}, doi = {10.3109/17435390.2013.831500}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23909703}, author = {Ucciferri, N and Collnot, E. M. and Gaiser, B. and Tirella, A and Stone, V. and C. Domenici and Lehr, C.-M. and A. Ahluwalia} } @conference {2144, title = {Increased Instability of Heartbeat Dynamics in Parkinson{\textquoteright}s Disease}, booktitle = {Computers in Cardiology}, year = {2013}, keywords = {Bioengineering}, author = {R. Barbieri and L. Citi and G. Valenza and M. Guerrisi and S. Orsolini and C. Tessa and S. Diciotti and N. Toschi} } @conference {2137, title = {Instantaneous bispectral characterization of the autonomic nervous system through a point-process nonlinear model}, booktitle = {World Congress on Medical Physics and Biomedical Engineering}, year = {2013}, pages = {530{\textendash}533}, publisher = {Springer Berlin Heidelberg}, organization = {Springer Berlin Heidelberg}, address = {May 26-31, 2012, Beijing, China}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and E. P. Scilingo and R. Barbieri} } @conference {2142, title = {Instantaneous nonlinear assessment of complex cardiovascular dynamics by laguerre-volterra point process models}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE}, year = {2013}, pages = {6131{\textendash}6134}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and R. Barbieri} } @conference {1814, title = {A Mobile Biosensor to detect Cardiorespiratory Activity for Stress Tracking}, booktitle = {IEEE 7th International Conference on Pervasive Computing Technologies for Healthcare (PervasiveHealth)}, year = {2013}, pages = {440 - 445 }, address = {Venice, Italy}, abstract = {

Stress is an increasingly recognized phenomenon that has negative effects on growing numbers of people. Stress assessment is a complex issue, but different studies have shown that monitoring user psychophysiological parameter during daily life can be greatly helpful in stress evaluation. In this study a wearable biosensor platform able to collect physiological and behavioral parameters is reported. The developed wearable platform, in terms of hardware and processing algorithms, is described. Moreover the use of this wearable biosensor platform in combination with advanced simulation technologies, such as virtual reality offer interesting opportunities for innovative personal health-care solutions to stress. A recently founded European project, "INTERSTRESS - Interreality in the management and treatment of stress-related disorders," will take into account these relevant aspects.

}, keywords = {Bioengineering}, issn = {978-1-4799-0296-5 }, author = {N. Carbonaro and A. Tognetti and G. Anania and D. De Rossi and P. Cipresso and A. Gaggioli and G. Riva} } @article {1808, title = {Modeling and Characterization of Extensible Wearable Textile-Based electrogoniometers}, journal = {IEEE Sensors Journal}, volume = {13}, year = {2013}, pages = {217 - 228}, abstract = {

Measuring and monitoring through wearable technology parameters related to human movement, posture, and gesture are gaining momentum because of their wide range of potential applications in daily-life conditions. In previous studies, carbon elastomers (CEs) have been used as strain sensors. Recent developments of CE sensors mathematical modeling demonstrated that the CEs can be used as electrogoniometers. It was proved that for small local curvatures of CE layers, the resistance of a strip constituting a layer depends only on the total curvature of the same layer and not on the particular shape that the sensor keeps in adherence with a surface. Further, it was proved, theoretically and experimentally, that a double-layer configuration provides better accuracy with respect to a single-layer configuration. These results have been obtained under the hypothesis that the device was bent, but not extended. In this paper, we substituted the inextensible insulating layer in the sensors with an elastic one, allowing the system to extend its length. This improvement required further study to make it fit for biomechanical applications following epithelial deformations produced by joint movements and minimizes skin motion artifacts.

}, keywords = {Bioengineering}, issn = {1530-437X}, doi = {10.1109/JSEN.2012.2211099}, author = {F. Lorussi and S. Galatolo and R. Bartalesi and D. De Rossi} } @article {2136, title = {Mood recognition in bipolar patients through the PSYCHE platform: Preliminary evaluations and perspectives}, journal = {Artificial Intelligence In Medicine}, volume = {57}, year = {2013}, pages = {49{\textendash}58}, keywords = {Bioengineering}, author = {G. Valenza and C. Gentili and A Lanata and E. P. Scilingo} } @article {2289, title = {NEuronMOrphological analysis tool: open-source software for quantitative morphometrics}, journal = {Front. Neuroinform.}, volume = {7}, year = {2013}, keywords = {Bioengineering}, doi = {10.3389/fninf.2013.00002.c}, author = {Billeci, L. and C. Magliaro and G. Pioggia and A. Ahluwalia} } @article {1783, title = {A new approach to fabricate agarose microstructures}, journal = {Polymers Advanced Technologies}, year = {2013}, keywords = {Bioengineering}, doi = {10.1002/pat.3162}, author = {C. De Maria and J. Rincon and A.A. Duarte and G. Vozzi and Boland, T} } @conference {2141, title = {A nonlinear heartbeat dynamics model approach for personalized emotion recognition}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE}, year = {2013}, pages = {2579{\textendash}2582}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and A Lanata and E. P. Scilingo and R. Barbieri} } @conference {1813, title = {Novel Spiking Neuron-Astrocyte Networks based on NoNlinearTransistor-Like Models of Tripartite Synapses}, booktitle = {Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC{\textquoteright}13)}, year = {2013}, address = {Osaka, Japan}, abstract = {

In this paper a novel and efficient computational implementation of a Spiking Neuron-Astrocyte Network (SNAN) is reported. Neurons are modeled according to the Izhikevich formulation and the neuron-astrocyte interactions are intended as tripartite synapsis and modeled with the previ- ously proposed nonlinear transistor-like model. Concerning the learning rules, the original spike-timing dependent plasticity is used for the neural part of the SNAN whereas an ad-hoc rule is proposed for the astrocyte part. SNAN performances are compared with a standard spiking neural network (SNN) and evaluated using the polychronization concept, i.e., number of co-existing groups that spontaneously generate patterns of polychronous activity. The astrocyte-neuron ratio is the biologically inspired value of 1.5. The proposed SNAN shows higher number of polychronous groups than SNN, remarkably achieved for the whole duration of simulation (24 hours).

}, keywords = {Bioengineering}, author = {G. Valenza and L. Tedesco and A Lanata and D. De Rossi and E. P. Scilingo} } @conference {2243, title = {Piezoresistive Goniometer Network for Sensing Gloves}, booktitle = {Proceedings of the XIII Mediterranean Conference on Medical and Biological Engineering and Computing}, year = {2013}, pages = {1547{\textendash}1550}, publisher = {Springer International Publishing}, organization = {Springer International Publishing}, abstract = {

This paper presents a kinesthetic glove realized with knitted piezoresistive fabric (KPF) sensor technology. The glove forefinger area is sensorized by two KPF goniometers obtained on the same piezoresistive substrate. The piezoresistive textile is used for the realization of both electrogoniometers and connections, thus avoiding mechanical constraints due to metallic wires. Sensors are characterized in comparison with commercial goniometers. The glove behavior is pointed out in terms of methacarpal-phalangeal and interphalangeal joint movement reconstruction.

}, keywords = {Bioengineering}, doi = {10.1007/978-3-319-00846-2_382}, author = {G. Dalle Mura and F. Lorussi and A. Tognetti and G. Anania and N. Carbonaro and M. Pacelli and R. Paradiso and D. De Rossi} } @article {2139, title = {Point-Process Nonlinear Models with Laguerre and Volterra Expansions: Instantaneous Assessment of Heartbeat Dynamics}, journal = {IEEE Transactions on Signal Processing}, volume = {61}, year = {2013}, pages = {2914{\textendash}2926}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and E. P. Scilingo and R. Barbieri} } @inbook {1810, title = {Preliminary Implementation of Context-Aware Attention System for Humanoid Robots}, booktitle = {Biomimetic and Biohybrid Systems (Proc. Second International Conference, Living Machines 2013)}, volume = {8064}, number = {Lecture Notes in Computer Science}, year = {2013}, pages = {457-459}, publisher = {Springer-Verlag}, organization = {Springer-Verlag}, abstract = {

A context-aware attention system is fundamental for regulating the robot behaviour in a social interaction since it enables social robots to actively select the right environmental stimuli at the right time during a multiparty social interaction. This contribution presents a modular context-aware attention system which drives the robot gaze. It is composed by two modules: the scene analyzer module manages incoming data flow and provides a human-like understanding of the information coming from the surrounding environment; the attention module allows the robot to select the most important target in the perceived scene on the base of a computational model. After describing the motivation, we report the proposed system and the preliminary test.

}, keywords = {Bioengineering}, issn = {978-3-642-39801-8}, doi = {10.1007/978-3-642-39802-5_65}, author = {A. Zaraki and D. Mazzei and Lazzeri, N. and M. Pieroni and D. De Rossi} } @article {1782, title = {Pressure-activated microsyringe composite scaffold of poly(L-lactic acid) and carbon nanotubes for bone tissue engineering}, journal = {Journal of Apllied polymer science}, volume = {129}, year = {2013}, pages = {528{\textendash}536}, keywords = {Bioengineering}, author = {G. Vozzi and C. Corallo and C. Daraio} } @article {1784, title = {Silk Fibroin/Gelatin Blend Films Crosslinked with Enzymes for Biomedical Applications}, year = {2013}, keywords = {Bioengineering}, doi = {10.1002/mabi.201300156}, author = {P. Taddei and V. Chiono and A. Anghileri and G. Vozzi and G. Freddi and G. Ciardelli} } @conference {1793, title = {{SpHyGa: fabrication of hepatic lobule replicas using tissue derived material composites}}, booktitle = {ESB 2013}, year = {2013}, pages = {ID 520}, address = {Madrid}, keywords = {Bioengineering}, author = {M. La Marca and Tirella, A and G. Mattei and A. Ahluwalia} } @article {2281, title = {SQPR 3.0: A Sensorized Bioreactor for Modulating Cardiac Phenotype}, journal = {Procedia Engineering}, volume = {59}, year = {2013}, pages = {219{\textendash}225}, abstract = {

In cardiac tissue engineering, the use of bioreactors is fundamental for applying controlled mechanical stimuli on cells and recreate a physiological environment for cardiomyocyte cultures. This work is focused on the design of a sensorized Squeeze Pressure bioreactor (SQPR 3.0) able to apply a periodic contactless hydrodynamic pressure on tissue constructs. This system was then tested with H2c9, a murine cardiomyoblast cell line, to investigate the effect of different stimulation times (2h, 24h, 30h) on cell shape and cardiotypic marker expression.

}, keywords = {Bioengineering}, issn = {18777058}, doi = {10.1016/j.proeng.2013.05.114}, url = {http://linkinghub.elsevier.com/retrieve/pii/S187770581301028X}, author = {S. Giusti and F. Pagliari and Vozzi, F. and Tirella, A and D. Mazzei and Cabiati, M and S. del Ry and A. Ahluwalia} } @article {1790, title = {{Strain rate viscoelastic analysis of soft and highly hydrated biomaterials.}}, journal = {Journal of biomedical materials research. Part A}, year = {2013}, abstract = {

Measuring the viscoelastic behaviour of highly hydrated biological materials is challenging because of their intrinsic softness and labile nature. In these materials it is difficult to avoid pre-stress and therefore to establish precise initial stress and strain conditions for lumped parameter estimation using creep or stress-relaxation tests. We describe a method ($ε$M or epsilon dot method) for deriving the viscoelastic parameters of soft hydrated biomaterials which avoids pre-stress and can be used to rapidly test degradable samples. Standard mechanical tests are first performed compressing samples using different strain rates. The dataset obtained is then analysed to mathematically derive the material{\textquoteright}s viscoelastic parameters. In this work a stable elastomer, PDMS, and a labile hydrogel, gelatin, were first tested using the $ε$M, in parallel stress-relaxation was used to compare lumped parameter estimation. After demonstrating that the elastic parameters are equivalent and that the estimation of short time constants is more precise using the proposed method, the viscoelastic behaviour of porcine liver was investigated using this approach. The results show that the constitutive parameters of hepatic tissue can be quickly quantified without the application of any pre-stress and before the onset of time dependent degradation phenomena.

}, keywords = {Bioengineering}, issn = {1552-4965}, doi = {10.1002/jbm.a.34914}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23946054}, author = {Tirella, A and G. Mattei and A. Ahluwalia} } @inbook {1811, title = {Towards a Believable Social Robot}, booktitle = {Biomimetic and Biohybrid Systems (Proc. Second International Conference, Living Machines 2013)}, number = {Lecture Notes in Computer Science}, year = {2013}, pages = {393-395}, publisher = {Springer-Verlag}, organization = {Springer-Verlag}, abstract = {

Two perspectives define a human being in his social sphere: appearance and behaviour. The aesthetic aspect is the first significant element that impacts a communication while the behavioural aspect is a crucial factor in evaluating the ongoing interaction. In particular, we have more expectations when interacting with anthropomorphic robots and we tend to define them believable if they respect human social conventions. Therefore researchers are focused both on increasingly anthropomorphizing the embodiment of the robots and on giving the robots a realistic behaviour.This paper describes our research on making a humanoid robot socially interacting with human beings in a believable way.

}, keywords = {Bioengineering}, issn = {978-3-642-39801-8}, doi = {10.1007/978-3-642-39802-5_45}, author = {Lazzeri, N. and D. Mazzei and A. Zaraki and D. De Rossi} } @conference {1802, title = {Towards a controlled and monitorable hepatic micro-environment}, booktitle = {Advanced Cell Culture}, year = {2013}, address = {Liverpool, UK}, keywords = {Bioengineering}, author = {Tirella, A and La Marca, M and Carroll, L. A. and Aylott, J and A. Ahluwalia} } @conference {1502, title = {3D SOFT-MI: novel microfabrication method of 3D molecular imprinted structures}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {132 - 133}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Carrabba, M and G. Vozzi} } @article {1479, title = {Are socially anxious individuals less empathic? A psychophysiological investigation of facial mimicry for emotional expressions}, journal = {International Journal of Psychophysiology}, volume = {85}, year = {2012}, pages = {375{\textendash}376}, keywords = {Bioengineering}, author = {Matu, S. and Cristea, I. and Cote{\c t}, C. and G. Valenza and C. Gentili and E. P. Scilingo and David, D.} } @conference {1504, title = {Characterization and modeling of mechanical behavior a discrete gradient structure}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {130 - 131}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Caputo, M and G. Vozzi and G. Mattei} } @article {1480, title = {Cognitive reappraisal and acceptance distinctively impact heart rate variability in socially anxious individuals}, journal = {International Journal of Psychophysiology}, volume = {85}, year = {2012}, pages = {339}, keywords = {Bioengineering}, author = {Cristea, I. and G. Valenza and C. Gentili and Tatar, A.S. and E. P. Scilingo and David, D.} } @conference {1801, title = {Continuous functionally graded materials (cFGMs) for TE}, booktitle = {TERMIS 3rd World Congress}, year = {2012}, address = {Vienna, Austria}, abstract = {

Biological structures are not uniform but possess spatially distributed functions and properties, or functional gradients. To ensure functional, mechanical and structural integration, a tissue engineered (TE) scaffold has to reproduce these functional gradients. However the fabrication of functionally graded materials is challenging and usually an experimental trial-and-error approach is used. In this work we present a controlled method for the fabrication of cFGMs using the gravitational sedimentation of discrete solid particles within a primary fluid phase. To have an overall control over particle distribution, a time-varying dynamic viscosity solution (i.e. thermo-sensitive) was used as fluid phase. Computational fluid dynamic models were developed to have a fine control over particle distribution. Biomimetic osteochondral cFGMs scaffolds were fabricated using hydroxyapatite (HA) and gelatin. Glutaraldehyde was used to covalently bind gelatin-HA graded scaffolds. Mechanical properties were measured and correlated as a function of HA volume fraction. SEM-EDX analysis was used to further characterise HA content and its distribution within gelatin-HA cFGMs. Finally gelatin-HA cFGMs scaffold were seeded using periosteum derived progenitor cells, to investigate how the HA gradient modulates cell response. This approach represents an innovative yet simple tool for the fabrication of tailored cFGMs with biologically and physiologically relevant gradients for TE applications.

}, keywords = {Bioengineering}, author = {G. Mattei and A. Ahluwalia and Ferretti, C and Mattioli-Belmonte, M. and Tirella, A} } @conference {1482, title = {On the deconvolution analysis of electrodermal activity in bipolar patients}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE}, year = {2012}, pages = {6691{\textendash}6694}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {A. Greco and A Lanata and G. Valenza and Rota, G. and N. Vanello and E. P. Scilingo} } @conference {1498, title = {Design, characterization and modeling of microfabricated Soft-MI for ophthalmologic applications.}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {204 - 205}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {La Vecchia, C and G. Vozzi} } @article {1469, title = {Dominant Lyapunov exponent and approximate entropy in heart rate variability during emotional visual elicitation}, journal = {Frontiers in Neuroengineering}, volume = {5}, year = {2012}, keywords = {Bioengineering}, author = {G. Valenza and Allegrini, P. and A Lanata and E. P. Scilingo} } @article {1478, title = {Eye gaze patterns in emotional pictures}, journal = {Journal of Ambient Intelligence and Humanized Computing}, year = {2012}, pages = {1{\textendash}11}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and E. P. Scilingo} } @conference {1506, title = {Finite element model for PAM scaffolds}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {74 - 75}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Pimentel, R and G. Vozzi} } @conference {1503, title = {Fluid dynamics characterization of a microfluidic concentration gradient maker}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {152 - 153}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {G. Orsi and G. Vozzi} } @article {1330, title = {Functionally Graded Materials (FGMs) with predictable and controlled gradient profiles: computational modelling and realisation}, journal = {International Journal for Computational Methods in Engineering Science \& Mechanics (CMES)}, year = {2012}, pages = {accepted}, keywords = {Bioengineering}, author = {G. Mattei and Tirella, A and A. Ahluwalia} } @article {1475, title = {Gait and Anthropometric Profile Biometrics: A Step Forward}, journal = {Second Generation Biometrics: The Ethical, Legal and Social Context}, year = {2012}, pages = {105{\textendash}127}, keywords = {Bioengineering}, author = {Ioannidis, D. and Tzovaras, D. and Mura, G.D. and M. Ferro and G. Valenza and A. Tognetti and G. Pioggia} } @conference {1265, title = {HEFES: an Hybrid Engine for Facial Expressions Synthesis to control human-like androids and avatars}, booktitle = {BIOROB2012}, year = {2012}, pages = {195 - 200}, address = {Rome, Italy}, keywords = {Bioengineering}, author = {D. Mazzei and Lazzeri, N. and Hanson, D. and D. De Rossi} } @inbook {1494, title = {Hydrogels with 3D Gradient of Mechanical Properties}, booktitle = {Hydrogels: Synthesis, Characterization and Applications}, number = {Biochemistry Research Trends}, year = {2012}, edition = {online edition}, chapter = {Hydrogels with 3D Gradient of Mechanical Properties }, keywords = {Bioengineering}, author = {G. Orsi and Carta, V and G. Vozzi} } @conference {1499, title = {Hydrogels with 3D gradient of mechanical properties}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {200 - 201}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Carta, V and G. Orsi and G. Vozzi} } @article {1329, title = {The impact of fabrication parameters and substrate stiffness in direct writing of living constructs}, journal = {Biotechnology progress}, volume = {28}, year = {2012}, pages = {1315{\textendash}1320}, abstract = {

Biomolecules and living cells can be printed in high-resolution patterns to fabricate living constructs for tissue engineering. To evaluate the impact of processing cells with rapid prototyping (RP) methods, we modeled the printing phase of two RP systems that use biomaterial inks containing living cells: a high-resolution inkjet system (BioJet) and a lower-resolution nozzle-based contact printing system (PAM(2) ). In the first fabrication method, we reasoned that cell damage occurs principally during drop collision on the printing surface, in the second we hypothesize that shear stresses act on cells during extrusion (within the printing nozzle). The two cases were modeled changing the printing conditions: biomaterial substrate stiffness and volumetric flow rate, respectively, in BioJet and PAM(2) . Results show that during inkjet printing impact energies of about 10(-8) J are transmitted to cells, whereas extrusion energies of the order of 10(-11) J are exerted in direct printing. Viability tests of printed cells can be related to those numerical simulations, suggesting a threshold energy of 10(-9) J to avoid permanent cell damage. To obtain well-defined living constructs, a combination of these methods is proposed for the fabrication of scaffolds with controlled 3D architecture and spatial distribution of biomolecules and cells. {\textcopyright} 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012.

}, keywords = {Bioengineering}, issn = {1520-6033}, doi = {10.1002/btpr.1586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22736619}, author = {Tirella, A and A. Ahluwalia} } @conference {1500, title = {Indirect m-fabrication using Pam2 system}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {166 - 167}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {De Acutis, A and C. De Maria and G. Vozzi} } @conference {1505, title = {Influence of substrate stiffness on behaviour of satellite cells}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {78 - 79}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Gattazzo, F and Urciuolo, A and Bonaldo, P and G. Vozzi} } @conference {1483, title = {Instantaneous estimation of high-order nonlinear heartbeat dynamics by Lyapunov exponents}, booktitle = {2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, year = {2012}, pages = {13{\textendash}16}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {L. Citi and G. Valenza and R. Barbieri} } @conference {1497, title = {Mathematical modelling of Endothelin-1 effect on hepatocytes,}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {205 - 206}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Valvano, G and G. Orsi and M. A. Guzzardi and Vozzi, F. and G. Vozzi} } @conference {1804, title = {Monitoring cell culture 3D microenvironments: oxygen and pH nano-sensors within hydrogels}, booktitle = {National Conference of Bioengineering}, year = {2012}, address = {Rome, Italy}, abstract = {

Ratiometric pH and O2 nanosensors were fabricated independently using a fluorophore that produces a signal proportional to the concentration of the analyte of interest, and a second fluorophore that produces a reference signal, insensitive to the analyte of interest. These fluorophores emit at different wavelengths and were either entrapped or covalently bound, within an inert optically transparent polymeric matrix. In this work uniform sized 3D micro-scaled alginate hydrogel constructs of approximately 100-300 $μ$m were fabricated. Through dual incorporation of HepG2 cells and nanosensors within these alginate constructs we aim to have a real-time, non-invasive method to measure microenvironmental pH and O2 content. Ratiometric fluorescent output from the microenvironment is used to monitor O2 concentrations and pH during cell culture. Measurements show that 3D micro-scaled constructs are suitable for cell growth and proliferation. Moreover O2 and pH values within the hydrogel cellularised microspheres are shown to have physiological values that enable the maintenance of the hepatic phenotype

}, keywords = {Bioengineering}, author = {Tirella, A and Carroll, L. A. and Aylott, J and A. Ahluwalia} } @conference {1486, title = {Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent}, booktitle = {2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, year = {2012}, pages = {3124{\textendash}3127}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {L. Citi and G. Valenza and Purdon, P.L. and Brown, E.N. and R. Barbieri} } @conference {1800, title = {{Monitoring microconstructs: cell and nanosensor encapsulation in alginate micro-beads}}, booktitle = {TERMIS 3rd World Congress}, year = {2012}, address = {Vienna, Austria}, abstract = {

Monitoring and controlling the microenvironment of cell cultures is an ongoing challenge for many researchers. Much research has been conducted characterising individual aspects such as 3D architecture, mechanical properties, biochemicals, etc. The biggest deficits in existing models for monitoring analytes within the cellular environment is the lack of appropriate means for non invasive, real-time and integrated monitoring of the cellular responses. Nanosensors can overcome these issues: they are porous polymeric nanoparticles that are sensitive to a range of analytes including pH and O2. Microfabrication techniques are innovative tools to obtain controlled microstructures with a defined 3D architecture. In this work uniform sized 3D micro-scaled hydrogel constructs of approximately 300-400 um diameter were fabricated. Through dual incorporation of cells and nanosensors within these constructs we aim to have a real-time, non invasive method to measure microenvironmental pH value and O2 content. Ratiometric fluorescent output from the microenvironment is used to monitor O2 and pH during cell culture. Measurements show that 3D micro-scaled constructs are suitable for cell growth and proliferation. Moreover O2 content and pH within hydrogel cellularised microspheres are shown to have physiological values which enable the maintenance of the hepatic phenotype.

}, keywords = {Bioengineering, Nanotools}, author = {Tirella, A and A. Ahluwalia and Aylott, J and Carroll, L. A.} } @conference {1803, title = {A multi-stimuli environment for cardiac tissue engineering}, booktitle = {TERMIS 3rd World Congress}, year = {2012}, address = {Vienna, Austria}, abstract = {

The identification of the ideal cell source to generate cardiac tissue able to integrate into the host myocardium and with the contractile system is crucial for cardiac engineering. Amongst different cell sources so far proposed, human adult Cardiac Progenitor Cells (hCPCs) show the ability to proliferate and differentiate toward cardiac lineages when grown in appropriate microenvironmental conditions. It is widely accepted that conventional 2D cultures may provide a physiological environment for growing cells. For this reason the need to have an engineered microenvironment, matching physiological requirements, is crucial. A 3D context with spatial and time varying distribution of regulatory factors using mechanically matched scaffolds and bioreactors could represent an in vitro cell culture model being able to more closely reflects the in vivo conditions. In the present study, the possibility of using biocompatible and biodegradable scaffolds of collagen based or derivatives hydrogels in combination with Linneg/Sca-1pos hCPCs gathered from human heart biopsies was investigated. Bio-constructs were placed in the low shear, high flow MCmB (MultiCompartment modular Bioreactor) and the combined effects of dynamic culture conditions and 3D scaffolds on cell morphology and differentiation were studied in order to investigate the possibility of fabricating stem cell-derived cardiac patches to replace infarcted tissue.

}, keywords = {Bioengineering, Bioreactors, Dynamic 3D Cultures}, author = {Tirella, A and A. Ahluwalia and P. Di Nardo and Gaudiello, E and S. Giusti and F. Pagliari} } @conference {1501, title = {Natural bioactive matrix for cartilage tissue engineering}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {161 - 162}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {F. Montemurro and G. Vozzi} } @conference {1797, title = {New method for the viscoelastic analysis of soft and highly hydrated biomaterials}, booktitle = {National Conference of Bioengineering}, year = {2012}, address = {Rome, Italy}, abstract = {

The role of materials mechanical properties is a new frontier for the evaluation of cell/material interaction, as well as for the determination of healthy/pathological state of a tissue. In these sense there is the need to have a unique method to measure materials viscoelastic properties. However, concerning with soft and highly hydrated constructs, the experimental set-up to precisely measure these properties is challenging because of the difficulty in defining zero stress or strain. To overcome these problems, we propose a novel and unique testing and data analysis technique (ERM) to derive materials viscoelastic properties. Results derived with this method can be compared to the ones obtained with standard testing techniques for viscoelastic materials. Pre-conditioning problems of testing soft and floppy materials are thus overcome, giving rise to have an accurate measure of viscous and elastic moduli of both hydrated materials and soft biological tissues. Small variations of measured properties can be also monitored with high precision, allowing a deeper investigation on the role of the scaffolding material or of tissue{\^a}{\texteuro}{\texttrademark}s extracellular matrix (respectively in cell culture systems or in biomechanics measurements for the characterisation of soft tissues).

}, keywords = {Bioengineering}, author = {Tirella, A and G. Mattei and A. Ahluwalia} } @conference {1495, title = {A novel approach to fabricate agarose microstructures,}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti, pp 341-342, Rome}, year = {2012}, keywords = {Bioengineering}, author = {C. De Maria and Boland, T and G. Vozzi} } @article {1476, title = {A novel EDA glove based on textile-integrated electrodes for affective computing}, journal = {Medical and Biological Engineering and Computing}, year = {2012}, pages = {1{\textendash}10}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and E. P. Scilingo} } @article {1493, title = {A Novel Method to Produce Immobilised Biomolecular Concentration Gradients to Study Cell Activities: Design and Modelling}, journal = {MOLECULAR BIOTECHNOLOGY}, volume = {50}, year = {2012}, pages = {99-107}, keywords = {Bioengineering}, issn = {1073-6085}, doi = {10.1007/s12033-011-9411-9}, author = {G. Vozzi and Lenzi, T and F. Montemurro and Pardini, C and Vaglini, F and A. Ahluwalia} } @article {1472, title = {Oscillations of Heart Rate and Respiration Synchronize During Affective Visual Stimulation}, journal = {Information Technology in Biomedicine, IEEE Transactions on}, volume = {16}, year = {2012}, pages = {683{\textendash}690}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and E. P. Scilingo} } @article {1331, title = {The PAM2 system: a multilevel approach for fabrication of complex three-dimensional microstructures}, journal = {Rapid Prototyping Journal}, volume = {18}, year = {2012}, pages = {299{\textendash}307}, keywords = {Bioengineering}, doi = {10.1108/13552541211231725}, author = {Tirella, A and C. De Maria and G. Criscenti and G. Vozzi and A. Ahluwalia} } @article {1333, title = {Rapid Prototyping Composite and Complex Scaffolds with PAM2}, journal = {Methods in Molecular Biology}, volume = {868}, year = {2012}, pages = {57{\textendash}69}, keywords = {Bioengineering}, author = {G. Vozzi and Tirella, A and A. Ahluwalia} } @conference {2282, title = {Real Time and In-Situ control of environmental parameters in a modular bioreactor}, booktitle = {Journal of tissue engineering and regenerative medicine}, volume = {6 Suppl 1}, year = {2012}, pages = {331}, address = {Vien, Austria}, abstract = {

Many researchers now recognize the importance of the external environment in which cells are cultured for cell function and differentiation. Most of the systems able to apply physiological-like stimuli also need a classical incubator or a specifically designed system to control the environmental parameters at some distance from the cells. Here, a standalone platform for cell, tissue and organ culture is described. The SUITE (Supervising Unit for In-vitro Testing) system can control local environmental variables like pH, temperature and hydrostatic pressure over long periods, to provide the optimal environment for cells outside the classical incubator and also to apply mechanical and chemical stimuli to simulate the physiological milieu. The SUITE platform is used with Multi-Compartmental modular Bioreactors (MCmB) to perform dynamic cultures of hepatocytes as in-vitro liver model. Preliminary tests demonstrated the capability of the system to maintain the target parameters for more than 72 h generating different hydrostatic pressures (20{\^a}{\texteuro}{\textquotedblleft}30{\^a}{\texteuro}{\textquotedblleft}40{\^a}{\texteuro}{\textquotedblleft}50 mmHg). Then, two bioreactors were connected in series and cultured for 24 h in the SUITE platform with hydrostatic pressures of 20{\^a}{\texteuro}{\textquotedblleft}30{\^a}{\texteuro}{\textquotedblleft}40 mmHg. Static and dynamic controls were placed in the classical humidified incubator at 37{\^A}{\textdegree}C, 5\% CO2. The results show that cell function is enhanced in SUITE at up to 30 mmHg of hydrostatic pressure, as confirmed by viability, metabolic function and morphological analysis.

}, keywords = {Bioengineering}, doi = {10.1002/term.1586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22941753}, author = {S. Giusti and D. Mazzei and A. Ahluwalia} } @conference {1264, title = {Realistic Humanlike Robots for Treatment of ASD, Social Training, and Research; Shown to Appeal to Youths with ASD, Cause Physiological Arousal, and Increase Human-to-Human Social Engagement}, booktitle = {Realistic Humanlike Robots for Treatment of Autism, PETRA 2012}, year = {2012}, pages = {1-7}, keywords = {Bioengineering}, author = {Hanson, D. and D. Mazzei and Garver, C. and D. De Rossi and Stevenson, M.} } @conference {1507, title = {Realization and characterization of bilayer scaffold with molecularly imprinted hydrogel layer,}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {65 - 66}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Morelli, L and G. Vozzi} } @article {1334, title = {Realization of a poro-elastic ultrasound replica of pulmonary tissue}, journal = {Biomatter}, volume = {2}, year = {2012}, pages = {27{\textendash}26}, keywords = {Bioengineering}, url = {http://www.landesbioscience.com/journals/biomatter/article/19835/}, author = {Spinelli, A and Vinci, B. and Tirella, A and Matteucci, M and Gargani, L and A. Ahluwalia and C. Domenici and Picano, E and Chiarelli, P} } @conference {2283, title = {Replicating the 3D cardiomyocyte environment in the squeeze pressure bioreactor}, booktitle = {Journal of tissue engineering and regenerative medicine}, volume = {6 Suppl 1}, year = {2012}, pages = {341}, keywords = {Bioengineering}, doi = {10.1002/term.1586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22941753}, author = {S. Giusti and Tirella, A and Galli, E and Vozzi, F. and Cabiati, M and A. Ahluwalia} } @conference {1792, title = {Replicating the cardiac environment in the Squeeze Pressure Bioreactor}, booktitle = {TERMIS 3rd World Congress}, year = {2012}, keywords = {Bioengineering}, author = {S. Giusti and Tirella, A and Galli, E and Vozzi, F. and Cabiati, M and A. Ahluwalia} } @conference {1496, title = {Rheological characterization of vitreous humoranalogous}, booktitle = {Congresso Nazionale di Bioingegneria 2012 Atti}, year = {2012}, pages = {207 - 208}, address = {Roma, Italy}, keywords = {Bioengineering}, author = {Fogli, G and G. Orsi and G. Vozzi} } @article {1327, title = {Riboflavin and collagen: New crosslinking methods to tailor the stiffness of hydrogels}, journal = {Materials Letters}, volume = {74}, year = {2012}, pages = {58{\textendash}61}, abstract = {

Fabricating materials with tailored mechanical properties is a challenge and crucial for their successful application in a variety of fields such as tissue engineering. Here collagen and riboflavin were used to create hydrogels with controlled mechanical properties mimicking those of soft tissues (e.g. liver). Collagen-based hydrogels were obtained using a two-step gelation method. Firstly a physical gelation step (i.e. modulation of temperature and pH) was used to fix a specific shape; then photo-initiated cross-links were formed to increase the stiffness. Specifically the chemical cross-linking step was initiated with UV (ultra-violet) radiation to obtain riboflavin derivatised radical polymerization of collagen chains. Cylindrical shaped samples with controlled dimensions were fabricated, and then tested using compressive loading. We show that the compressive elastic modulus of collagen-based hydrogels can be tuned between 0.9 and 3.6 kPa by changing collagen concentration, irradiation with UV in the presence of riboflavin and freeze-drying.

}, keywords = {Bioengineering}, issn = {0167577X}, doi = {10.1016/j.matlet.2012.01.036}, url = {http://dx.doi.org/10.1016/j.matlet.2012.01.036}, author = {Tirella, A and Liberto, T and A. Ahluwalia} } @article {1463, title = {The Role of Nonlinear Dynamics in Affective Valence and Arousal Recognition}, journal = {Affective Computing, IEEE Transactions on}, volume = {3}, year = {2012}, pages = {237{\textendash}249}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and E. P. Scilingo} } @article {1491, title = {Small-Strain Modeling of Helical Dielectric Elastomer Actuators}, journal = {IEEE/ASME TRANSACTIONS ON MECHATRONICS}, volume = {17}, year = {2012}, pages = {318{\textendash}325}, keywords = {Bioengineering}, issn = {1083-4435}, author = {F. Carpi and D. De Rossi} } @conference {1484, title = {Speech analysis for mood state characterization in bipolar patients}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE}, year = {2012}, pages = {2104{\textendash}2107}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {N. Vanello and Guidi, A. and C. Gentili and Werner, S. and G. Bertschy and G. Valenza and A Lanata and E. P. Scilingo} } @article {1485, title = {Tetravariate Point-Process Model for the Continuous Characterization of Cardiovascular-Respiratory Dynamics during Passive Postural Changes}, year = {2012}, keywords = {Bioengineering}, author = {Orini, M. and G. Valenza and L. Citi and R. Barbieri} } @conference {1481, title = {Using Laguerre expansion within point-process models of heartbeat dynamics: A comparative study}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE}, year = {2012}, pages = {29{\textendash}32}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and L. Citi and E. P. Scilingo and R. Barbieri} } @article {1514, title = {Cooperation of Biological and Mechanical Signals in Cardiac Progenitor Cell Differentiation}, journal = {ADVANCED MATERIALS}, year = {2011}, keywords = {Bioengineering}, issn = {0935-9648}, author = {S. Pagliari and A.C. Vilela-Silva and G. Forte and F. Pagliari and C. Mandoli and G. Vozzi and S. Pietronave and M. Prat and S. Licoccia and A. Ahluwalia and E. Traversa and M. Minieri and P. Di Nardo} } @article {1477, title = {Daytime naps improve motor imagery learning}, journal = {Cognitive, Affective, \& Behavioral Neuroscience}, year = {2011}, pages = {1{\textendash}10}, keywords = {Bioengineering}, author = {Debarnot, U. and Castellani, E. and G. Valenza and Sebastiani, L. and Guillot, A.} } @conference {1272, title = {Development and evaluation of a social robot platform for therapy in autism}, booktitle = {Proc. Annual Int Engineering in Medicine and Biology Society,EMBC Conf. of the IEEE}, year = {2011}, pages = {4515{\textendash}4518}, keywords = {Bioengineering}, doi = {10.1109/IEMBS.2011.6091119}, author = {D. Mazzei and Lazzeri, N. and Billeci, L. and Igliozzi, R. and A Mancini and A. Ahluwalia and Muratori, F. and D. De Rossi} } @article {1279, title = {Dispositivo per tomografia ad impedenza elettrica}, year = {2011}, keywords = {Bioengineering}, issn = {PI2011A000124}, author = {Baldi, G. and D. Mazzei and Gervasi, V.} } @conference {1474, title = {EEG complexity drug-induced changes in disorders of consciousness: A preliminary report}, booktitle = {Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE}, year = {2011}, pages = {3724{\textendash}3727}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and Carboncini, MC and Virgillito, A. and Creatini, I. and Bonfiglio, L. and Rossi, B. and A Lanata and E. P. Scilingo} } @conference {1467, title = {Eye tracking and pupil size variation as response to affective stimuli: A preliminary study}, booktitle = {Pervasive Computing Technologies for Healthcare (PervasiveHealth), 2011 5th International Conference on}, year = {2011}, pages = {78{\textendash}84}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {A Lanata and Armato, A. and G. Valenza and E. P. Scilingo} } @article {1285, title = {A flexible bioreactor system for constructing in vitro tissue and organ models.}, journal = {Biotechnol Bioeng}, volume = {108}, year = {2011}, month = {Sep}, pages = {2129{\textendash}2140}, abstract = {

To develop in vitro models of cells, tissues and organs we have designed and realized a series of cell culture chambers. Each chamber is purpose designed to simulate a particular feature of the in vivo environment. The bioreactor system is user friendly, and the chambers are easy to produce, sterilize and assemble. In addition they can be connected together to simulate inter-organ or tissue cross-talk. Here we discuss the design philosophy of the bioreactor system and then describe its construction. Preliminary results of validation tests obtained with hepatocytes and endothelial cells are also reported. The results show that endothelial cells are extremely sensitive to small levels of shear stress and that the presence of heterotypic signals from endothelial cells enhances the endogenous metabolic function of hepatocytes.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.1002/bit.23164}, author = {Vozzi, F. and D. Mazzei and Vinci, B. and G. Vozzi and Sbrana, T. and Ricotti, L. and Forgione, N. and A. Ahluwalia} } @article {1511, title = {HEMETBeta: improvement of hepatocyte metabolism mathematical model}, journal = {COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING}, year = {2011}, keywords = {Bioengineering}, issn = {1025-5842}, author = {G. Orsi and C. De Maria and M. A. Guzzardi and Vozzi, F. and G. Vozzi} } @article {1277, title = {High throughput sensorized bioreactor for applying hydrodynamic pressure and shear stress stiumli on cell cutlures}, year = {2011}, month = {10/2011}, keywords = {Bioengineering}, issn = {WO 2011/121377}, author = {A. Ahluwalia and C. De Maria and D. Mazzei and G. Vozzi} } @conference {1799, title = {How dimension a substrate for the realisation of controlled micro- and bio-inspired environment}, booktitle = {Euromat-FEMS}, year = {2011}, address = {Montpellier, France}, abstract = {

European Congress and Exhibition on Advanced Materials and Processes - Oral

}, keywords = {Bioengineering}, author = {Tirella, A and A. Ahluwalia and C. De Maria and Vozzi, F. and G. Vozzi and Sandri, T and Sassano, D and Cognolato, L} } @inbook {1789, title = {{Inherently Bio-Active Scaffolds: Intelligent Constructs to Model the Stem Cell Niche}}, booktitle = {Myocardial Tissue Engineering}, series = {Studies in Mechanobiology, Tissue Engineering and Biomaterials}, volume = {6}, year = {2011}, pages = {29{\textendash}47}, publisher = {Springer Berlin Heidelberg}, organization = {Springer Berlin Heidelberg}, address = {Berlin, Heidelberg}, abstract = {

The oft-abused phrase {\^a}{\texteuro}{\oe}genes load the gun, environment pulls the trigger{\^a}{\texteuro} can be applied to stem cells and stem cell niches as well as to cell{\^a}{\texteuro}{\textquotedblleft}material interfaces. Much is known about cell{\^a}{\texteuro}{\textquotedblleft}material interaction in general, perhaps a little less about how these interactions condition cell phenotype. With the increasing interest in stem cells and, in particular, their applications in tissue regeneration, the regulation of the stem cell microenvironment through modulation of intuitive or smart materials and structures, or what we term IBAS (Inherently Bio-Active Scaffolds) is poised to become a major field of research. Here, we discuss how cardiac regeneration strategies have undergone a gradual shift from the emphasis on biochemical signals and basic biology to one in which the material or scaffold plays a major role in establishing an equilibrium state. From being a constant battle or tug-of-war between the cells and synthetic environments, we conceive IBAS as intuitively responding to the cell{\^a}{\texteuro}{\texttrademark}s requirements to instate a sort of equilibrium in the system.

}, keywords = {Bioengineering}, isbn = {978-3-642-18055-2}, doi = {10.1007/978-3-642-18056-9}, url = {http://www.springerlink.com/content/j3k541l113233424/}, author = {P. Di Nardo and M. Minieri and Tirella, A and G. Forte and A. Ahluwalia}, editor = {Boccaccini, A. R. and Harding, S. E.} } @article {1508, title = {LTI Models for 3-Iodothyronamine Time Dynamics: A Multiscale View.}, journal = {IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING}, volume = {58}, year = {2011}, pages = {3153 - 3157}, keywords = {Bioengineering}, issn = {0018-9294}, author = {G. Orsi and Frascarelli, S and R. Zucca and G. Vozzi} } @article {1510, title = {Melt Extruded PU Hollow Fibers for Nerve Regeneration: In vivo Study}, journal = {VETERINARY RESEARCH}, year = {2011}, keywords = {Bioengineering}, issn = {0928-4249}, author = {G. Vozzi and F. Dini and S. Burchielli and C. Salvadori and C. De Maria and V. Chiono and G. Barsotti and G. Ciardelli and F. Carlucci and R. Roni} } @conference {1805, title = {Modelling and realisation of smart graded hydrogel scaffolds}, booktitle = {Euromat-FEMS}, year = {2011}, address = {Montpellier, France}, abstract = {

European Congress and Exhibition on Advanced Materials and Processes - Poster F12-P-2-08

}, keywords = {Bioengineering}, author = {Tirella, A and G. Mattei and F. Montemurro and G. Vozzi and A. Ahluwalia} } @article {1466, title = {Motor imagery effectiveness for mirror reversed movements}, journal = {Cognitive, Affective, \& Behavioral Neuroscience}, volume = {11}, year = {2011}, pages = {22{\textendash}31}, keywords = {Bioengineering}, author = {Debarnot, U. and G. Valenza and Champely, S. and E. P. Scilingo and D. De Rossi and Guillot, A.} } @inbook {1286, title = {Multi-Compartmental Modular Bioreactor as Innovative System for Dynamic Cell Cultures and Co-Cultures}, booktitle = {Bioreactors: Design, Properties and Applications}, number = {978-1-62100-164-5}, year = {2011}, pages = {159 - 178}, publisher = {Nova Science Publishers, Inc}, organization = {Nova Science Publishers, Inc}, chapter = {Multi-Compartimental Modular Bioreactor as Innovative System for Dynamic Cell Cultures and Co-Cultures}, abstract = {

In this chapter, the design, fabrication process and preliminary tests of a Multi- Compartmental Modular Bioreactor used as a system for dynamic cell cultures and co-cultures is described. Although the microwell (MW) plate has become a standard in cell culture, the complexity of the physiological environment is not replicated in petri dishes or microplates. All cells are exquisitely sensitive to their micro-environment which is rich with cues from other cells and from mechanical stimuli due to flow, perfusion and movement. Microwells do not offer any form of dynamic chemical or physical stimulus to cells, such as concentration gradients, flow, pressure or mechanical stress. This is a major limitation in experiments investigating cellular responses in-vitro since the complex interplay of mechanical and biochemical factors is absent. Most researchers and industry have started to accept that classical in vitro experiments offer poor predictive value or mechanistic understanding and are shifting their interests to new technologies such as bioreactors. For this reason, a large number of bioreactor systems for cell culture have been recently designed and described. With the purpose of developing cell culture models to establish a physiological-like interaction between different cell types, a novel Multi-Compartmental Modular Bioreactor (MCmB)was realized. The modular chamber was designed with shape and dimensions similar to the 24-MultiWell allowing an easy transfer of microwell protocols. The MCmB consists of a cell culture chamber made of bio-compatible silicon polymer, with excellent self-sealing proprieties, transparency and flexibility. The modular chambers can be also connected together in series or in parallel as desired, in order to allow cell-cell cross-talk or replicate in vitro models of metabolism or diseases using allometric design principles. In this chapter we describe the bioreactor design process starting from a finite-element method (FEM) model, developed in order to study the shear stress and the oxygen concentration at the cell surface. A further version of the MCmB is also described, in which a semipermeable membrane is placed into the bioreactor allowing to create a double-chamber system (MCmB-dc) for biological barriers simulation like for example lung or intestine. Allometric methods for designing in-vitro organ models using combinations of different cell types or tissues cultured in different chambers are also presented. Allometric laws mathematically correlate non linear quantities such as organ mass, blood flow, blood retention time and metabolic rate. Using these laws the modules can be assembled in various configurations enabling organ and system physiology to be recapitulated in vitro. Preliminary experiments using the modules are also described.

}, keywords = {Bioengineering}, issn = {978-1-62100-164-5}, author = {D. Mazzei and S. Giusti and Sbrana, T. and A. Ahluwalia}, editor = {Antolli, P. G. and Zhiming Liu} } @article {1473, title = {A neuron-astrocyte transistor-like model for neuromorphic dressed neurons}, journal = {Neural Networks}, year = {2011}, keywords = {Bioengineering}, author = {G. Valenza and G. Pioggia and Armato, A. and M. Ferro and E. P. Scilingo and D. De Rossi} } @article {1490, title = {PAM2 (Piston Assisted Microsyringe): A New Rapid Prototyping Technique for Biofabrication of Cell Incorporated Scaffolds}, journal = {Tissue Eng Part C Methods}, volume = {17}, year = {2011}, keywords = {Bioengineering}, doi = {10.1089/ten.tec.2010.0195}, author = {Tirella, A and Vozzi, F. and G. Vozzi and A. Ahluwalia} } @article {1513, title = {Poly(ester urethane) Guides for Peripheral Nerve Regeneration}, journal = {MACROMOLECULAR BIOSCIENCE}, year = {2011}, keywords = {Bioengineering}, issn = {1616-5187}, author = {V. Chiono and Sartori, S and Rechichi, A and Tonda-Turo, C and G. Vozzi and Vozzi, F. and D{\textquoteright}Acunto, M and C. Salvadori and F. Dini and G. Barsotti and F. Carlucci and S. Burchielli and Nicolino, S and Audisio, C and Perroteau, I and P. Giusti and G. Ciardelli} } @article {1460, title = {Robust multiple cardiac arrhythmia detection through bispectrum analysis}, journal = {Expert Systems with Applications}, volume = {38}, year = {2011}, pages = {6798{\textendash}6804}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and Mancuso, C. and E. P. Scilingo} } @article {1512, title = {Sensing scaffolds to monitor cellular activity using impedance measurements}, journal = {BIOSENSORS \& BIOELECTRONICS}, year = {2011}, keywords = {Bioengineering}, issn = {0956-5663}, author = {Whulanza, Y and Ucciferri, N and C. Domenici and G. Vozzi and A. Ahluwalia} } @article {2284, title = {Squeeze pressure bioreactor: a hydrodynamic bioreactor for noncontact stimulation of cartilage constructs}, journal = {Tissue engineering. Part C, Methods}, volume = {17}, year = {2011}, pages = {757{\textendash}64}, abstract = {

A novel squeeze pressure bioreactor for noncontact hydrodynamic stimulation of cartilage is described. The bioreactor is based on a small piston that moves up and down, perpendicular to a tissue construct, in a fluid-filled chamber. Fluid displaced by the piston generates a pressure wave and shear stress as it moves across the sample, simulating the dynamic environment of a mobile joint. The fluid dynamics inside the squeeze pressure bioreactor was modeled using analytical and computational methods to simulate the mechanical stimuli imposed on a construct. In particular, the pressure, velocity field, and wall shear stress generated on the surface of the construct were analyzed using the theory of hydrodynamic lubrication, which describes the flow of an incompressible fluid between two surfaces in relative motion. Both the models and in-situ pressure measurements in the bioreactor demonstrate that controlled cyclic stresses of up to 10 kPa can be applied to tissue constructs. Initial tests on three-dimensional scaffolds seeded with chondrocytes show that glycosaminoglycan production is increased with regard to controls after 24 and 48 h of cyclic noncontact stimulation in the bioreactor.

}, keywords = {Bioengineering}, issn = {1937-3392}, doi = {10.1089/ten.TEC.2011.0002}, url = {http://online.liebertpub.com/doi/abs/10.1089/ten.tec.2011.0002 http://www.ncbi.nlm.nih.gov/pubmed/21410315}, author = {C. De Maria and S. Giusti and D. Mazzei and A. Crawford and A. Ahluwalia} } @inbook {2285, title = {The Squeeze Pressure Bioreactor: Design and Modelling of a Non-Contact Device for Mechanical Stimulation of Tissue Engineered Constructs}, booktitle = {Bioreactors: Design, Properties and Applications}, year = {2011}, pages = {199{\textendash}214}, publisher = {Nova Science Publishers, Inc.}, organization = {Nova Science Publishers, Inc.}, address = {Hauppauge NY}, abstract = {

Diseases of hyaline cartilage represent one of the major health problems, especially in industrialized countries with high life expectancy. The erosion of the articulating surfaces of joints, known as osteoarthritis, currently affects more than 200 million citizens worldwide, and more than 50\% of the patients need or will need a surgical treatment. Articular cartilage is a three dimensional avascular tissue, which covers the ends of all synovial joints. During normal daily function, articular cartilage can be repeatedly subjected to forces up to several time body weight, but it is able to provide articulating joints with a nearly frictionless motion. Despite its tremendously important function, articular cartilage has limited capacity for auto regeneration after degenerative and rheumatic diseases, like arthritis, as well as traumatic injuries. Cartilage problems are a huge and still unsolved medical issue, which therefore represents one of the most important tissue engineering targets requiring high quality products as fast as possible. For this reason, the possibility to recreate in vitro cartilage substitutes as a real alternative to total joint replacement represents an increasing and hopeful market, in which many research groups are still working. At the moment, one of the main findings in invitro cartilage studies is the importance of the role of mechanical stimuli and dynamic loads for the chondrocytes growth and differentiation. Several studies using cartilage explants or chondrocytes seeded in 3D scaffolds have shown that mechanical compressive loads affect the cells metabolic activity and their matrix production. In order to simulate the in vivo environment, the use of bioreactors is becoming fundamental: bioreactors can provide the chemical and mechanical signals that optimize tissue development. Furthermore, bioreactors could be an important instrument to reduce the cost of clinical studies, used as in vitro predictors of in vivo performance. In this way,the use of bioreactors can reduce animal studies, helping the scientists to focus their attention in the right direction before starting pre-clinical studies, which are usually more expensive than preliminary research. In the past few years, several systems for the application of different mechanical stimuli to chondrocytes have been developed. Most of these can generate biomechanical-like forces such as the direct compression, tensile and shear forces, or hydrostatic pressure, in order to stimulate the articular chondrocyctes to increase their matrix production. Generally, the most important requirements that a culture system has to satisfy are high reliability and usability, perfect sterility, easy control of all the important culture parameters and low cost. In this work, a new system, inspired by the synovial environment of mobile joints and able to apply an innovative type of stimulation on articular chondrocytes is described and modeled. The SQPR (SQueeze PRessure) bioreactor chamber is designed to impose a cyclic hydrodynamic pressure on cell cultures, constructs or tissues slices. The basic principle of this new system is the generation of a localized contact less overpressure on articular chondrocytes, using a simple vertical piston movement. This kind of stimulation is particularly useful for neo-tissue or fresh-constructs, in which cells require a dynamic environment to maintain their differentiate state, but at the same time do not tolerate direct compression or high shear stress. When the piston moves down, a controlled hydrodynamic overpressure and a shear stress is generated over the cell surface, stimulating the chondrocytes to improve their matrix production. The fluid dynamics inside the SQPR bioreactor is illustrated from an analytical and numerical point of view. We show how these models can predict the pressure, velocity field and wall shear stress generated on the cell surface of the construct. The bioreactor design is presented in detail and validation tests on chondrocytes are described.

}, keywords = {Bioengineering}, url = {https://www.novapublishers.com/catalog/product\_info.php?products\_id=22653}, author = {S. Giusti and A. Ahluwalia and C. De Maria}, editor = {Antolli, P. G. and Z. Liu} } @article {1488, title = {Substrate stiffness influences high resolution printing of living cells with an ink-jet system}, journal = {Journal of bioscience and bioengineering}, volume = {112}, year = {2011}, pages = {79{\textendash}85}, abstract = {

The adaptation of inkjet printing technology for the realisation of controlled micro- and nano-scaled biological structures is of great potential in tissue and biomaterial engineering. In this paper we present the Olivetti BioJet system and its applications in tissue engineering and cell printing. BioJet, which employs a thermal inkjet cartridge, was used to print biomolecules and living cells. It is well known that high stresses and forces are developed during the inkjet printing process. When printing living particles (i.e., cell suspensions) the mechanical loading profile can dramatically damage the processed cells. Therefore computational models were developed to predict the velocity profile and the mechanical load acting on a droplet during the printing process. The model was used to investigate the role of the stiffness of the deposition substrate during droplet impact and compared with experimental investigations on cell viability after printing on different materials. The computational model and the experimental results confirm that impact forces are highly dependent on the deposition substrate and that soft and viscous surfaces can reduce the forces acting on the droplet, preventing cell damage. These results have high relevance for cell bioprinting; substrates should be designed to have a good compromise between substrate stiffness to conserve spatial patterning without droplet coalescence but soft enough to absorb the kinetic energy of droplets in order to maintain cell viability.

}, keywords = {Bioengineering}, issn = {1347-4421}, doi = {10.1016/j.jbiosc.2011.03.019}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21497548}, author = {Tirella, A and Vozzi, F. and C. De Maria and G. Vozzi and Sandri, T and Sassano, D and Cognolato, L and A. Ahluwalia} } @article {1278, title = {Supporto per camere di coltura cellulare}, year = {2011}, month = {11/2011}, keywords = {Bioengineering}, issn = {MI2011A002073}, author = {A. Ahluwalia and Sbrana, T. and D. Mazzei} } @article {1509, title = {Tuning polycaprolactone-carbon nanotube composites for bone tissue engineering scaffolds}, journal = {MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS}, year = {2011}, keywords = {Bioengineering}, issn = {0928-4931}, author = {Mattioli-Belmonte, M. and G. Vozzi and Whulanza, Y and Seggiani, M and Fantauzzi, V and Orsini, G and A. Ahluwalia} } @article {1468, title = {074 EARLY EVALUATION OF THE CONNECTIONS BETWEEN AUTISM AND ALTERATIONS OF MOVEMENT}, journal = {Parkinsonism \& Related Disorders}, volume = {16}, year = {2010}, pages = {S22}, keywords = {Bioengineering}, author = {Nardini, E. and G. Valenza and Mancuso, C. and Armato, A. and A Lanata and E. P. Scilingo and D. De Rossi} } @article {1520, title = {Automated software for analysis of ciliary beat frequency and metachronal wave orientation in Primary Ciliary Dyskinesia}, journal = {EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY}, year = {2010}, keywords = {Bioengineering}, issn = {0937-4477}, author = {G. MANTOVANI and M. PIFFERI and G. Vozzi} } @article {1276, title = {Contenitore per alimenti caldi e simili}, year = {2010}, keywords = {Bioengineering}, issn = {PI2009A000145}, author = {M. Bonini and R. Casati and M. Falorni and G Fantoni and M. Massei and D. Mazzei and M. Mazzuoli and G. Renucci} } @conference {1471, title = {The contribution of the phase spectrum in automatic multiple cardiac arrhythmias recognition in wearable systems}, booktitle = {Applied Sciences in Biomedical and Communication Technologies (ISABEL), 2010 3rd International Symposium on}, year = {2010}, pages = {1{\textendash}5}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {A Lanata and G. Valenza and E. P. Scilingo} } @conference {1529, title = {Engineered Skeletal Muscle using Pam Scaffold}, booktitle = {Congress of the European Society of Biomechanics, ESB 2010}, year = {2010}, keywords = {Bioengineering}, author = {D. Cei and E. Loro and A. Malena and C. De Maria and L. Vergani and G. Vozzi} } @conference {1532, title = {Enzymatic cross-linked hydrogel: role of Lysyl oxidase as an initiator of fibroblast inflammatory response}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {Tirella, A and G. Vozzi and N. Tirelli and A. Ahluwalia} } @article {1521, title = {Enzymatically crosslinked porous composite matrices for bone tissue regeneration}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, year = {2010}, keywords = {Bioengineering}, issn = {1549-3296}, author = {G. Ciardelli and GENTILE, P and V. Chiono and Mattioli-Belmonte, M. and G. Vozzi and Barbani, N and P. Giusti} } @conference {1271, title = {The FACE of autism}, booktitle = {Proc. IEEE RO-MAN}, year = {2010}, pages = {791{\textendash}796}, keywords = {Bioengineering}, doi = {10.1109/ROMAN.2010.5598683}, author = {D. Mazzei and Billeci, L. and Armato, A. and Lazzeri, N. and Cisternino, A. and G. Pioggia and Igliozzi, R. and Muratori, F. and A. Ahluwalia and D. De Rossi} } @article {1332, title = {Finite element modelling and design of a concentration gradient generating bioreactor: Application to biological pattern formation and toxicology}, journal = {Toxicology in vitro}, volume = {24}, year = {2010}, pages = {1828{\textendash}1837}, abstract = {

This paper describes the use of a microfluidic gradient maker for the toxicological analysis of some conventional biomolecules such as hydrogen peroxide and a local anaesthetic, lidocaine on different cell cultures, human endothelial cells and myoblasts, respectively. The microfluidic device was designed and simulated using COMSOL Multiphysics(R) and the concentration gradient in the microfluidic network was analysed through a fluid-dynamic and mass-transport study. Subsequently the device was fabricated with soft lithography, casting PDMS in a master to obtain channels about 250mum deep. Hydrogen peroxide was tested on human endothelial cells, while lidocaine was tested on C2C12 myoblasts and an analysis was performed using propidium iodide staining followed by an imaging processing routine to obtain quantitative dose-response profiles in the gradient maker. The results show that the Gradient Maker (GM) bioreactor is a more sensitive method for detection of cell toxicity, and compared with testing of drug toxicity using microwells with individual cell cultures, allows one shot testing with a single cell culture exposed to a large number of concentrations. Moreover, the Gradient Maker was also modelled in order to realise biological pattern formation using two morphogenes acting as activator and inhibitor with varying diffusion rates.

}, keywords = {Bioengineering}, issn = {1879-3177}, doi = {10.1016/j.tiv.2010.05.010}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20580814}, author = {G. Vozzi and D. Mazzei and Tirella, A and Vozzi, F. and A. Ahluwalia} } @conference {1527, title = {Hydrogel Bioactive Scaffold Fabricated with PAM2 System: Realization of Complex Shaped Scaffold with a Homogeneous Dispersion of HepG2 cells}, booktitle = {NIP Conference}, year = {2010}, keywords = {Bioengineering}, author = {Tirella, A and Vozzi, F. and G. Vozzi and A. Ahluwalia} } @article {1284, title = {In vitro liver model using microfabricated scaffolds in a modular bioreactor.}, journal = {Biotechnol J}, volume = {5}, year = {2010}, month = {Feb}, pages = {232{\textendash}241}, abstract = {

Hepatocyte function on 3-D microfabricated polymer scaffolds realised with the pressure-activated microsyringe was tested under static and dynamic conditions. The dynamic cell culture was obtained using the multicompartment modular bioreactor system. Hepatocyte cell density, glucose consumption, and albumin secretion rate were measured daily over a week. Cells seeded on scaffolds showed an increase in cell density compared with monolayer controls. Moreover, in dynamic culture, cell metabolic function increased three times in comparison with static monolayer cultures. These results suggest that cell density and cell-cell interactions are mediated by the architecture of the substrate, while the endogenous biochemical functions are regulated by a sustainable supply of nutrients and interstitial-like flow. Thus, a combination of 3-D scaffolds and dynamic flow conditions are both important for the development of a hepatic tissue model for applications in drug testing and regenerative medicine.

}, keywords = {Bioengineering}, doi = {http://dx.doi.org/10.1002/biot.200900074}, author = {Vinci, B. and Cavallone, D. and G. Vozzi and D. Mazzei and C. Domenici and Brunetto, M. and A. Ahluwalia} } @article {1283, title = {A low shear stress modular bioreactor for connected cell culture under high flow rates.}, journal = {Biotechnol Bioeng}, volume = {106}, year = {2010}, month = {May}, pages = {127{\textendash}137}, abstract = {

A generic "system on a plate" modular multicompartmental bioreactor array which enables microwell protocols to be transferred directly to the bioreactor modules, without redesign of cell culture experiments or protocols is described. The modular bioreactors are simple to assemble and use and can be easily compared with standard controls since cell numbers and medium volumes are quite similar. Starting from fluid dynamic and mass transport considerations, a modular bioreactor chamber was first modeled and then fabricated using "milli-molding," a technique adapted from soft lithography. After confirming that the shear stress was extremely low in the system in the range of useful flow rates, the bioreactor chambers were tested using hepatocytes. The results show that the bioreactor chambers can increase or maintain cell viability and function when the flow rates are below 500 microL/min, corresponding to wall shear stresses of 10(-5) Pa or less at the cell culture surface.

}, keywords = {Bioengineering, Bioreactors}, doi = {http://dx.doi.org/10.1002/bit.22671}, author = {D. Mazzei and M. A. Guzzardi and S. Giusti and A. Ahluwalia} } @conference {1533, title = {Mechanical characterization of polymer cartilage scaffold at different pH}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {S. Romiti and G. Vozzi and C. De Maria and F. Montemurro} } @article {1282, title = {Modification of Pointing Performance in Altered Gravitational Environments}, journal = {Microgravity Science and Technology}, volume = {22}, year = {2010}, note = {

10.1007/s12217-009-9163-3

}, pages = {123-128}, abstract = {

The Fitts{\textquoteright} law describes a correlation between the time needed to complete basic tasks such as pointing movements and the level of knowledge of the specific target to be reached. While it has been largely proved in normal gravity, very few experiments have been carried out in altered gravitational conditions. In our experiment, four subjects were positioned in front of a panel where round targets were placed along a circumference. They carried out pointing movements towards the targets when these were switched on. The task time was acquired and processed off-line. In all the cases, the performance of each subject have been significantly modified in the altered gravitational environment and, in particular, hypergravity seems to affect motor performance more considerably than microgravity. Even if experiments involving several subjects and more complex tasks have to be carried out in order to confirm our findings, these results show that ergonomics could be strongly affected by the modification of gravity, especially during the first phase of exposure to gravity alteration.

}, keywords = {Bioengineering}, issn = {0938-0108}, doi = {http://dx.doi.org/10.1007/s12217-009-9163-3}, author = {Ciofani, G. and Migliore, A. and D. Mazzei and Carrozza, M. and P. Dario} } @article {1518, title = {Molecularly imprinted nanospheres for applications in a novel model biosensor-scaffold,}, journal = {SENSORS AND ACTUATORS. B, CHEMICAL}, year = {2010}, keywords = {Bioengineering}, issn = {0925-4005}, author = {MORELLI, I and V. Chiono and G. Vozzi and G. Ciardelli and SILVESTRI, D and P. Giusti} } @article {1516, title = {NEW BIOARTIFICIAL SYSTEMS AND BIODEGRADABLE SYNTHETIC POLYMERS FOR CARDIAC TISSUE ENGINEERING: A PRELIMINARY SCREENING}, journal = {BIOMEDICAL ENGINEERING. APPLICATIONS, BASIS, COMMUNICATIONS}, year = {2010}, keywords = {Bioengineering}, issn = {1016-2372}, author = {Rosellini, E and Cristallini, C and Barbani, N and G. Vozzi and D{\textquoteright}Acunto, M and G. Ciardelli and P. Giusti} } @article {1517, title = {Novel injectable hydrogel scaffold for cartilage repair based on natural polymers}, journal = {JOURNAL OF OSTEOLOGY AND BIOMATERIALS}, year = {2010}, keywords = {Bioengineering}, issn = {2036-6795}, author = {G. Mattei and F. Montemurro and Mattioli-Belmonte, M. and G. Vozzi} } @conference {1534, title = {Pam scaffold for heart tissue engineering}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {M. Nardi and C. De Maria and A. Ahluwalia and G. Vozzi} } @conference {1536, title = {Pam Scaffold For Tissue Engineering Of Skeletal Muscle}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {D. Cei and E. Loro and A. Malena and L. Vergani and G. Vozzi} } @conference {1531, title = {PAM2 microfabricated three-dimensional bioactive hydrogel systems: realisation of a hepatic-like structure}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {Tirella, A and Vozzi, F. and Vinci, B. and G. Vozzi and A. Ahluwalia} } @conference {1525, title = {PAM2 System: a Modular Approach for the Realisation of Complex Shaped Scaffold Able to Reproduce the Main Features of a Specific Micro-environment,}, booktitle = {2010 International Conference on Biofabrication, 4-6 October 2010, Philadelphia, USA}, year = {2010}, keywords = {Bioengineering}, author = {A. Ahluwalia and Tirella, A and G. Vozzi} } @conference {1464, title = {A pervasive activity management and rehabilitation support system for the elderly}, booktitle = {Pervasive Computing and Communications Workshops (PERCOM Workshops), 2010 8th IEEE International Conference on}, year = {2010}, pages = {813{\textendash}816}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Pioggia and Tartarisco, G. and G. Valenza and Ricci, G. and Volpi, L. and Siciliano, G. and Bonfiglio, S.} } @inbook {1522, title = {Rapid Prototyping Composite and Complex Scaffolds with PAM2}, booktitle = {Computer-Aided Tissue Engineering}, volume = {868}, number = {Methods in Molecular Biology}, year = {2010}, pages = {57-69}, chapter = {Rapid Prototyping Composite and Complex Scaffolds with PAM2}, keywords = {Bioengineering}, author = {G. Vozzi and Tirella, A and A. Ahluwalia} } @conference {1528, title = {Resident cardiac stem cells on PAM scaffold for Heart tissue engineering application}, booktitle = {Congress of the European Society of Biomechanics, ESB 2010}, year = {2010}, keywords = {Bioengineering}, author = {M. Nardi and C. De Maria and G. Forte and P. Di Nardo and A. Ahluwalia and G. Vozzi} } @conference {1530, title = {Sensorised "Smart" Scaffold to Monitor Cell Processes Based on Impedance Characteristics}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {Whulanza, Y and Ucciferri, N and G. Vozzi and A. Ahluwalia and C. Domenici} } @conference {1526, title = {Site Specific Nano-Tuning of Scaffolds Using Inkjet Printing}, booktitle = {NIP Conference}, year = {2010}, address = {Austin, Texas }, keywords = {Bioengineering}, author = {Tirella, A and F. Montemurro and Vinci, B. and Vozzi, F. and G. Vozzi and Sassano, D and Sandri, T and Cognolato, L and A. Ahluwalia} } @article {1519, title = {SOFT-MI: a novel microfabrication technique integrating Soft-lithography and Molecular imprinting for tissue engineering applications}, journal = {BIOTECHNOLOGY AND BIOENGINEERING}, year = {2010}, keywords = {Bioengineering}, issn = {0006-3592}, author = {G. Vozzi and MORELLI, I and Vozzi, F. and ANDREONI, C and SALSEDO, E and MORACHIOLI, A and P. Giusti and G. Ciardelli} } @conference {1535, title = {Soft-MI scaffold for tissue engineering applications}, booktitle = {Congresso Nazionale di Bioingegneria 2010}, year = {2010}, keywords = {Bioengineering}, author = {MORACHIOLI, A and G. Vozzi and F. Montemurro} } @article {1515, title = {Three-dimensional microfabricated scaffolds with cardiac extracellular matrix-like architecture}, journal = {INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS}, year = {2010}, keywords = {Bioengineering}, issn = {0391-3988}, author = {Rossellini, E and G. Vozzi and Barbani, N and P. Giusti and Cristallini, C} } @conference {1465, title = {Towards a smart glove: Arousal recognition based on textile electrodermal response}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE}, year = {2010}, pages = {3598{\textendash}3601}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and E. P. Scilingo and D. De Rossi} } @article {1541, title = {Development of a RGDS-peptide modified polyurethane for tissue regeneration}, journal = {ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY}, volume = {611}, year = {2009}, pages = {249{\textendash}250}, keywords = {Bioengineering}, issn = {0065-2598}, author = {Rechichi, A and Sartori, S and CAPORALE, A and G. Ciardelli and G. Vozzi and MAZZUCCO, L and PEGGION, E and P. Giusti} } @conference {1544, title = {ENMET: Endothelial Cell Metabolism Mathematical Model,}, booktitle = {2009 Ninth International Conference on Intelligent Systems Design and Applications}, year = {2009}, pages = {654 - 659}, keywords = {Bioengineering}, author = {G. Orsi and C. De Maria and Vozzi, F. and M. A. Guzzardi and A. Ahluwalia and G. Vozzi} } @conference {1462, title = {An FPGA based arrhythmia recognition system for wearable applications}, booktitle = {Intelligent Systems Design and Applications, 2009. ISDA{\textquoteright}09. Ninth International Conference on}, year = {2009}, pages = {660{\textendash}664}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {Armato, A. and Nardini, E. and A Lanata and G. Valenza and Mancuso, C. and E. P. Scilingo and D. De Rossi} } @article {1539, title = {Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(epsilon-caprolactone)}, journal = {BIOMEDICAL MICRODEVICES}, year = {2009}, pages = {1037-1050}, keywords = {Bioengineering}, issn = {1387-2176}, author = {V. Chiono and G. Vozzi and Vozzi, F. and C. Salvadori and F. Dini and F. Carlucci and ARISPICI, M and S. Burchielli and DI SCIPIO, F and GEUNA, S and FORNARO, M and TOS, P and Nicolino, S and Audisio, C and Perroteau, I and CHIARAVALLOTI, A and C. Domenici and P. Giusti and G. Ciardelli} } @article {1542, title = {A new library of HEMET model: Insulin effects on hepatic metabolism}, journal = {COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE}, volume = {94}, year = {2009}, pages = {181{\textendash}189}, keywords = {Bioengineering}, issn = {0169-2607}, doi = {10.1016/j.cmpb.2008}, author = {CUTRONE, A and C. De Maria and Vinci, B. and Vozzi, F. and A. Ahluwalia and G. Vozzi} } @article {1328, title = {A phase diagram for microfabrication of geometrically controlled hydrogel scaffolds}, journal = {Biofabrication}, volume = {1}, year = {2009}, pages = {045002}, abstract = {

Hydrogels are considered as excellent candidates for tissue substitutes by virtue of their high water content and biphasic nature. However, the fact that they are soft, wet and floppy renders them difficult to process and use as custom-designed scaffolds. To address this problem alginate hydrogels were modeled and characterized by measuring stress-strain and creep behavior as well as viscosity as a function of sodium alginate concentration, cross-linking time and calcium ion concentration. The gels were then microfabricated into scaffolds using the pressure-assisted microsyringe. The mechanical and viscous characteristics were used to generate a processing window in the form of a phase diagram which describes the fidelity of the scaffolds as a function of the material and machine parameters. The approach can be applied to a variety of microfabrication methods and biomaterials in order to design well-controlled custom scaffolds.

}, keywords = {Bioengineering}, issn = {1758-5090}, doi = {10.1088/1758-5082/1/4/045002}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20811111}, author = {Tirella, A and Orsini, A and G. Vozzi and A. Ahluwalia} } @conference {1795, title = {Pneumatic module of PAM2 microfabrication system: realization of bio-inspired complex scaffolds}, booktitle = {3B International Conference in Bioprinting and Biofabrication}, year = {2009}, address = {Bordeaux, France}, abstract = {

poster

}, keywords = {Bioengineering}, author = {C. De Maria and Tirella, A and A. Ahluwalia and G. Vozzi} } @article {1540, title = {Polyurethane unimorph bender microfabricated with Pressure Assisted Microsyringe (PAM) for biomedical applications}, journal = {MATERIALS SCIENCE AND ENGINEERING. C}, volume = {29}, year = {2009}, pages = {1835{\textendash}1841}, keywords = {Bioengineering}, issn = {0928-4931}, author = {Tartarisco, G. and G. GALLONE and F. Carpi and G. Vozzi} } @article {1543, title = {Preparation and characterization of alginate/gelatin blend films for cardiac tissue engineering}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, volume = {91}, year = {2009}, pages = {447-453}, keywords = {Bioengineering}, issn = {1549-3296}, doi = {10.1002/jbm.a.32216}, author = {Rosellini, E and Cristallini, C and Barbani, N and G. Vozzi and P. Giusti} } @article {1538, title = {Simplified cell culture method for the diagnosis of atypical Primary Ciliary}, journal = {THORAX}, volume = {64}, year = {2009}, pages = {1077-81}, keywords = {Bioengineering}, issn = {0040-6376}, doi = {10.1136/thx.2008}, author = {M. PIFFERI and F. Montemurro and CANGIOTTI, A M and RAGAZZO, V and DI CICCO, M and Vinci, B. and G. Vozzi and MACCHIA, P and BONER, A L} } @conference {1633, title = {Analisi del battito ciliare nella discinesia ciliare tramite algoritmi di motion detection}, booktitle = {Discinesie ciliarie e malattie respiratorie croniche del bambino: dalla diagnosi differenziale alla qualit{\`a}~ della vita}, year = {2008}, pages = {{\textendash}}, address = {14-15 March 2008, Pisa, Italy}, keywords = {Bioengineering}, author = {G. MANTOVANI and M. A. Guzzardi and RAGAZZO, V and M. PIFFERI and G. Vozzi} } @inbook {1631, title = {Biomaterials fabrication and processing handbook}, year = {2008}, pages = {{\textendash}}, chapter = {Rapid Prototyping Methods for Tissue Engineering Applications}, keywords = {Bioengineering}, author = {G. Vozzi and A. Ahluwalia} } @conference {1642, title = {Biomimicry of PAM Microfabricated Hydrogel Scaffolds}, booktitle = {International Conference on Digital Printing Technologies Conference Proceedings}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {Tirella, A and G. Vozzi and A. Ahluwalia} } @article {1550, title = {Chitosan/gelatin blends for biomedical applications}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, volume = {86}, year = {2008}, pages = {311{\textendash}322}, keywords = {Bioengineering}, issn = {1549-3296}, author = {PULIERI, E and V. Chiono and G. Ciardelli and G. Vozzi and A. Ahluwalia and C. Domenici and Vozzi, F. and P. Giusti} } @article {1546, title = {Comparative study of porous and engineered biomaterials}, journal = {INTERNAL MEDICINE}, volume = {15}, year = {2008}, pages = {4{\textendash}8}, keywords = {Bioengineering}, issn = {0918-2918}, author = {Mattioli-Belmonte, M. and K KYRIAKIDOU and LUCARINI, G and ZIZZI, A and A. Ahluwalia and G. Vozzi} } @conference {1649, title = {Composite polyurethane and carbon black bimorph bender microfabricated with pressure assisted microsyringe (PAM) for biomedical applications}, year = {2008}, keywords = {Bioengineering}, author = {Tartarisco, G. and G. GALLONE and F. Carpi and G. Vozzi} } @article {1559, title = {Controlled in vitro growth of cell microtubes: towards the realisation of artificial microvessels}, journal = {BIOMEDICAL MICRODEVICES}, year = {2008}, keywords = {Bioengineering}, issn = {1387-2176}, author = {Migliore, A. and Vozzi, F. and G. Vozzi and A. Ahluwalia} } @article {1549, title = {Criticality of the Biological and Physical Stimuli Array Inducing Resident Cardiac Stem Cell Determination}, journal = {STEM CELLS}, volume = {26}, year = {2008}, pages = {2093{\textendash}2103}, keywords = {Bioengineering}, issn = {1066-5099}, author = {G. Forte and CAROTENUTO, F and F. Pagliari and S. Pagliari and COSSA, P and FIACCAVENTO, R and A. Ahluwalia and G. Vozzi and Vinci, B. and SERAFINO, A and RINALDI, A and E. Traversa and CAROSELLA, L and M. Minieri and P. Di Nardo} } @article {1629, title = {Degradable block polyurethanes from nontoxicbuilding blocks as scaffold materials to support cell growth and proliferation}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {1549-3296}, author = {Rechichi, A and G. Ciardelli and D{\textquoteright}Acunto, M and G. Vozzi and P. Giusti} } @article {1630, title = {Electroactive Carbon Nanotube Actuators: Soft-Lithographic Fabrication and Electro-chemical Modelling}, journal = {MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {0928-4931}, author = {A. Mazzoldi and M. Tesconi and A. Tognetti and W. Rocchia and G. Vozzi and G. Pioggia and A. Ahluwalia and D. De Rossi} } @article {1560, title = {Enzymatically-modified melt-extruded guides for peripheral nerve repair}, journal = {ENGINEERING IN LIFE SCIENCES}, year = {2008}, keywords = {Bioengineering}, issn = {1618-0240}, author = {V. Chiono and G. Ciardelli and G. Vozzi and CORTEZ, J and Barbani, N and GENTILE, P and P. Giusti} } @article {1556, title = {Genipin-crosslinked chitosan/gelatin blends for biomedical applications}, journal = {JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE}, year = {2008}, keywords = {Bioengineering}, issn = {0957-4530}, author = {V. Chiono and PULIERI, E and G. Vozzi and G. Ciardelli and A. Ahluwalia and P. Giusti} } @article {1547, title = {HEMET: mathematical model of biochemical pathways for simulation and prediction of HEpatocyte METabolism}, journal = {COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE}, volume = {92}, year = {2008}, pages = {121{\textendash}134}, keywords = {Bioengineering}, issn = {0169-2607}, author = {C. De Maria and GRASSINI, D and Vozzi, F. and Vinci, B. and A. Landi and A. Ahluwalia and G. Vozzi} } @article {1281, title = {A High-Throughput Bioreactor System for Simulating Physiological Environments}, journal = {IEEE T Ind Electron}, volume = {55}, year = {2008}, pages = {3273{\textendash}3280}, keywords = {Bioengineering}, doi = {10.1109/TIE.2008.928122}, author = {D. Mazzei and Vozzi, F. and Cisternino, A. and G. Vozzi and A. Ahluwalia} } @article {1275, title = {IMPROVED BIOREACTOR CHAMBER}, year = {2008}, keywords = {Bioengineering}, issn = {P121684GB}, author = {A. Ahluwalia and D. Mazzei and Vozzi, F.} } @article {1545, title = {In vitro engineering of the liver using multiple axis stimuli}, journal = {INTERNAL MEDICINE}, volume = {15}, year = {2008}, pages = {13{\textendash}15}, keywords = {Bioengineering}, issn = {0918-2918}, author = {Vinci, B. and G. Vozzi and AVOGARO, A and A. Ahluwalia} } @conference {1640, title = {Microfabbricazione di scaffold in alginato con propriet{\`a}~ meccaniche modulabili}, booktitle = {Congresso Nazionale Biomateriali 2008}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {Orsini, A and Tirella, A and A. Ahluwalia and G. Vozzi} } @conference {1634, title = {Microfabrication of Hydrogels scaffolds including cells and mechanical characterization}, booktitle = {Congresso Nazionale di Bioingegneria 2008}, year = {2008}, pages = {367-368}, address = {Pisa, Italy}, keywords = {Bioengineering}, author = {Tirella, A and G. Vozzi} } @conference {1794, title = {Microfluidic Gradient Maker for Pattern Generation}, booktitle = {TERMIS-EU}, year = {2008}, pages = {879}, address = {Porto, Portugal}, abstract = {

poster

}, keywords = {Bioengineering}, author = {Tirella, A and D. Mazzei and G. Vozzi and A. Ahluwalia} } @article {1489, title = {A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine}, journal = {Toxicology in vitro}, volume = {22}, year = {2008}, pages = {1957{\textendash}64}, abstract = {

A great deal of effort is being dedicated to the development of new devices able to conduct effective in vitro toxicology analyses. This paper describes the use of a microfluidic gradient maker for the toxicological analysis of two conventional local anesthetics, bupivacaine and lidocaine on cell cultures. The microfluidic device was designed and simulated using COMSOL Multiphysics and the concentration gradient in the microfluidic network was analysed through a fluidodynamic and diffusive study. Subsequently the device was fabricated with soft lithography, casting PDMS in a master to obtain channels about 250 microm deep. Both drugs were tested on C2C12 myoblasts and an analysis was performed using propidium iodide staining followed by an imaging processing routine to obtain quantitative dose-response profiles in the gradient maker. The system was critically compared with microwell-based toxicity testing. The results show that the GM is a more sensitive method for detection of cell toxicity, and compared with testing of drug toxicity using microwells with individual cell cultures, allows one shot testing with a single cell culture exposed to a large number of concentrations. However, the flow rates required to obtain a suitable concentration range across the device may damage shear sensitive cells.

}, keywords = {Bioengineering}, issn = {0887-2333}, doi = {10.1016/j.tiv.2008.09.016}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18940244}, author = {Tirella, A and Marano, M and Vozzi, F. and A. Ahluwalia} } @article {1274, title = {MULTI-CAVITY BIOREACTOR CHAMBER}, year = {2008}, keywords = {Bioengineering}, issn = {P122454GB}, author = {A. Ahluwalia and D. Mazzei and Vinci, B.} } @conference {1643, title = {Nanotechnology in Tissue Engineering}, booktitle = {Congresso Nazionale di Bioingegneria 2008}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {G. Ciardelli and V. Chiono and Rechici, A and Sartori, S and G. Vozzi and Bignardi, C and Georgiev, G and P. Giusti} } @conference {1644, title = {Nerve guide for peripheral nerve re generation}, year = {2008}, keywords = {Bioengineering}, author = {Tonda-Turo, C and V. Chiono and GEUNA, S and Perroteau, I and G. Vozzi and G. Ciardelli} } @article {1551, title = {Nerve regeneration using novel biomaterial supports}, journal = { Biomedicine and Pharmacotherapy }, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {0753-3322}, author = {G. Vozzi and V. Chiono and Vozzi, F. and C. Salvadori and F. Dini and F. Carlucci and ARISPICI, M and S. Burchielli and G. Ciardelli and P. Giusti} } @conference {1635, title = {Nerve regeneration using novel biomaterial supports}, booktitle = {Biomedicine \& Pharmacotherapy}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {G. Vozzi and V. Chiono and Vozzi, F. and C. Salvadori and F. Dini and F. Carlucci and ARISPICI, M and S. Burchielli and G. Ciardelli and P. Giusti} } @article {1558, title = {A New Bio-Inspired Robot Based on Senseless Motion: Theoretical study and Preliminary Technological Results}, journal = {MULTIDISCIPLINE MODELING IN MATERIALS AND STRUCTURES}, year = {2008}, keywords = {Bioengineering}, issn = {1573-6105}, author = {COTRONEO, A and G. Vozzi and GEROVASI, L and D. De Rossi} } @article {1553, title = {Optimization of PAM Scaffolds for Neural Tissue Engineering: Preliminary Study on an SH-SY5Y Cell Line}, journal = {TISSUE ENGINEERING, PART A}, year = {2008}, keywords = {Bioengineering}, issn = {1937-3341}, author = {KULLENBERG, J and ROSATINI, F and G. Vozzi and BIANCHI, F and A. Ahluwalia and C. Domenici} } @conference {1796, title = {PAM Composite Scaffold of PCL and Carbon NanoTubes for Bone Tissue Regeneration}, booktitle = {National Conference of Bioengineering}, year = {2008}, pages = {369}, address = {Pisa, Italy}, abstract = {

poster

}, keywords = {Bioengineering}, author = {Mattioli-Belmonte, M. and Fantauzzi, V and K KYRIAKIDOU and Tirella, A and A. Ahluwalia and G. Vozzi} } @article {1557, title = {PAM-microfabricated polyurethane scaffolds: in vivo and in vitro preliminary studies}, journal = {MACROMOLECULAR BIOSCIENCE}, year = {2008}, keywords = {Bioengineering}, issn = {1616-5187}, author = {G. Vozzi and Rechichi, A and F. Dini and C. Salvadori and Vozzi, F. and S. Burchielli and F. Carlucci and ARISPICI, M and G. Ciardelli and P. Giusti and A. Ahluwalia} } @article {1548, title = {A patented drop-free trocar for ophthalmic applications: design and realization [from mind to market]}, journal = {IEEE INDUSTRIAL ELECTRONICS MAGAZINE}, volume = {2}, year = {2008}, pages = {4{\textendash}8}, keywords = {Bioengineering}, issn = {1932-4529}, author = {Guerrini, P. and G. Vozzi and A. Ahluwalia and Palla, M.} } @article {1554, title = {Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(epsilon-caprolactone) blends for tissue engineering applications in the form of hollow fibers}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {1549-3296}, author = {V. Chiono and G. Ciardelli and G. Vozzi and SOTGIU, MG and Vinci, B. and C. Domenici and P. Giusti} } @article {1555, title = {Rapid-prototyped and salt-leached PLGA scaffolds condition cell morpho-functional behaviour}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {1549-3296}, author = {Mattioli-Belmonte, M. and G. Vozzi and K KYRIAKIDOU and PULIERI, E and LUCARINI, G and Vinci, B. and PUGNALONI, A and BIAGINI, G and A. Ahluwalia} } @conference {1641, title = {Realizzazione di strutture micro fabbricate tramite tecnica di micro Laser Sintering per applicazione alla Tissue Engineering}, booktitle = {Congresso Nazionale Biomateriali 2008}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {G. Criscenti and Tirella, A and A. Ahluwalia and P. Giusti and G. Vozzi} } @conference {1461, title = {Real-time discrimination of multiple cardiac arrhythmias for wearable systems based on neural networks}, booktitle = {Computers in Cardiology, 2008}, year = {2008}, pages = {1053{\textendash}1056}, publisher = {IEEE}, organization = {IEEE}, keywords = {Bioengineering}, author = {G. Valenza and A Lanata and M. Ferro and E. P. Scilingo} } @article {1628, title = {Surface modification of a synthetic polyurethane by plasma glow discharge: preparation and characterisation of bioactive monolayers}, journal = {REACTIVE \& FUNCTIONAL POLYMERS}, volume = {68}, year = {2008}, pages = {809{\textendash}821}, keywords = {Bioengineering}, issn = {1381-5148}, author = {Sartori, S and Rechichi, A and G. Vozzi and D{\textquoteright}Acunto, M and HEINE, E and P. Giusti and G. Ciardelli} } @conference {1639, title = {Sviluppo e caratterizzazione meccanica di scaffold a base di collagene per la rigenerazione della cartilagine}, booktitle = {Congresso Nazionale Biomateriali 2008}, year = {2008}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {G. Mattei and F. Montemurro and A. Ahluwalia and G. Vozzi} } @inbook {1632, title = {Tissue Engineering: Roles, Materials and Applications}, year = {2008}, pages = {{\textendash}}, chapter = {Gellan/Gelatin-Based Biomaterials for Tissue Engineering}, keywords = {Bioengineering}, author = {V. Chiono and G. Vozzi and G. Ciardelli} } @article {1400, title = {Underwater cartography for archaeology in the VENUS project}, journal = {GEOMATICA}, volume = {62}, year = {2008}, pages = {419{\textendash}427}, keywords = {Bioengineering}, issn = {1195-1036}, author = {P. Drap and J. SEINTURIER and G. Conte and A. Caiti and D. Scaradozzi and S. M. Zanoli and P. GAMBOGI} } @article {1655, title = {Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP}, journal = {EUROPEAN JOURNAL OF NEUROSCIENCE}, volume = {25}, year = {2007}, pages = {2741{\textendash}2754}, keywords = {Bioengineering}, issn = {0953-816X}, author = {RESTA, V. and NOVELLI, E. and G. Vozzi and SCARPA, C. and CALEO, M. and A. Ahluwalia and SOLINI, A. and SANTINI, E. and PARISI, V. and DI VIRGILIO, F. and GALLI-RESTA, L.} } @conference {1662, title = {Bioactive polyurethanes trough new functionalisation stretegies}, booktitle = {Biotechnical functionalisation of renewable polymeric materials}, year = {2007}, month = {16-17 April}, keywords = {Bioengineering}, author = {G. Ciardelli and Sartori, S and Rechichi, A and CAPORALE, A and S. BRONCO and G. Vozzi and P. Giusti} } @conference {1660, title = {Biomimetic materials for tissue engineering through enzyme mediated protein modification}, booktitle = {European Polymer Congress 2007 }, year = {2007}, month = {2-6 July}, address = {Portoroz, Slovenia}, keywords = {Bioengineering}, author = {G. Ciardelli and GENTILE, P and Mandrile, R. and V. Chiono and Barbani, N and Mattioli-Belmonte, M. and G. Vozzi and P. Giusti} } @conference {1657, title = {Cardiac and Mesenchymal Stem Cell Growth and Selective Differentiation on Three Dimensional Bioerodable Scaffolds}, booktitle = {Termis Eu-Meeting London (UK) 4-7 September 2007 Tissue Engineering 2007, 13 (7): 1647}, year = {2007}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {G. Forte and CAROTENUTO, F and G. Vozzi and COSSA, P and FIACCAVENTO, R and M. Minieri and F. Pagliari and S. Pagliari and Romano, R. and A. Ahluwalia and E. Traversa and P. Di Nardo} } @conference {1270, title = {Design and realisation of drop-free trocar for ophthalmic applications}, booktitle = {Proc. IEEE Int. Symp. Industrial Electronics ISIE 2007}, year = {2007}, pages = {2810{\textendash}2814}, keywords = {Bioengineering}, doi = {10.1109/ISIE.2007.4375056}, author = {Guerrini, P. and G. Vozzi and A. Ahluwalia and D. Mazzei and Palla, M. and Rizzo, S.} } @conference {1269, title = {Development of a high-throughput bioreactor system for biomedical applications}, booktitle = {Proc. IEEE Int. Symp. Industrial Electronics ISIE 2007}, year = {2007}, pages = {2788{\textendash}2792}, keywords = {Bioengineering}, doi = {10.1109/ISIE.2007.4375051}, author = {D. Mazzei and G. Vozzi and A. Ahluwalia and Cisternino, A.} } @conference {1658, title = {Hydroxyapatite/collagen composite matrices for bone reconstruction}, booktitle = {Termis Eu-Meeting - Tissue Engineering 2007}, year = {2007}, pages = {13 (7): 1708}, address = {London (UK) }, keywords = {Bioengineering}, author = {G. Ciardelli and GENTILE, P and Mandrile, R. and V. Chiono and Barbani, N and Mattioli-Belmonte, M. and G. Vozzi and P. Giusti} } @article {1652, title = {La rigenerazione nervosa negli innesti a polarit{\`a}~ invertita: dati a confronto tra applicazione sull{\textquoteright}uomo e analisi sperimentale su modello animale}, journal = {RIVISTA DI CHIRURGIA DELLA MANO}, year = {2007}, pages = {{\textendash}}, keywords = {Bioengineering}, author = {D. S. POGGI and Massarella, M. and Cerulli, G. and Caraffa, A. and S. Burchielli and Modenato, M. and Cantile, C. and G. Vozzi and C. De Maria and Lisanti, M. and Bonicoli, E. and Cantini, G.} } @article {1653, title = {Microfabrication for tissue engineering: rethinking the cells-on-a scaffold approach}, journal = {JOURNAL OF MATERIALS CHEMISTRY}, year = {2007}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {0959-9428}, author = {G. Vozzi and A. Ahluwalia} } @article {1656, title = {Microfabrication of fractal polymeric structures for capillary morphogenesis: applications in therapeutic angiogenesis and in the engineering of vascularized tissue}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS}, volume = {81}, year = {2007}, pages = {462{\textendash}468}, keywords = {Bioengineering}, issn = {1552-4981}, author = {BIANCHI, F and ROSI, M. and G. Vozzi and EMANUELI, C. and MADEDDU, P. and A. Ahluwalia} } @conference {1661, title = {Molecularly Imprinted Polymers with Recognition Properties Toward Fibronectin H-Gly-Arg-Gly-Asp-Ser-OH Sequence}, booktitle = {European Polymer Congress 2007}, year = {2007}, month = {2-6 July}, address = {Portoroz, Slovenia}, keywords = {Bioengineering}, author = {Rechichi, A and Rosellini, E and G. Ciardelli and Barbani, N and G. Vozzi and P. Giusti and Cristallini, C} } @article {1654, title = {New biomedical devices with selective peptide recognition properties. Part 1: Characterization and cytotoxicity of molecularly imprinted polymers}, journal = {JOURNAL OF CELLULAR AND MOLECULAR MEDICINE}, year = {2007}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {1582-1838}, author = {Rechichi, A and Cristallini, C and VITALE, U. and G. Ciardelli and Barbani, N and G. Vozzi and P. Giusti} } @conference {1659, title = {New strategies in polymer functionalisation}, booktitle = {Biosurf, 28-31 August 2007}, year = {2007}, pages = { European Cells and Materials Vol. 14. Suppl. 3}, address = {Zurich (Switzerland)}, keywords = {Bioengineering}, author = {Sartori, S and Rechichi, A and G. Ciardelli and CAPORALE, A and G. Vozzi and MAZZUCCO, L} } @conference {LSFD-06, title = {Bi-modal Transducer-based Wearable System for Cardiac Monitoring}, booktitle = {Fourth IASTED International Conference on Biomedical Engineering}, year = {2006}, month = {February}, pages = {92-97}, address = {Innsbruck, Austria}, keywords = {Bioengineering}, author = {A Lanata and E. P. Scilingo and R. Francesconi and D. De Rossi} } @article {1273, title = {Sensore di flusso tattile e di parametri ambientali}, year = {2006}, keywords = {Bioengineering}, issn = {PI2006A000119}, author = {G. Vozzi and Cisternino, A. and Colombo, D. and D. Mazzei and Migliore, A.} } @inbook {DS06, title = {Skin-like sensor arrays}, booktitle = {Encyclopedia of Sensors}, year = {2006}, pages = {535-556}, publisher = {American Scientific Publishers}, organization = {American Scientific Publishers}, keywords = {Bioengineering, Haptics}, author = {D. De Rossi and E. P. Scilingo} } @inbook {DLMS01, title = {Wearable Mechanosensing and Emerging Technologies in Fabric-based Actuation}, booktitle = {Intelligent Textiles for Personal Protection and Safety}, volume = {3}, year = {2006}, pages = {55-64}, publisher = {IOS Press}, organization = {IOS Press}, edition = { }, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and F. Lorussi and E. P. Scilingo and A. Tognetti} } @inbook {DCLPST05, title = {Electroactive fabrics and wearable man-machine interfaces}, booktitle = {Wearable Electronics and Photonics}, year = {2005}, pages = {59-80}, publisher = {Woodhead Publishing Ltd}, organization = {Woodhead Publishing Ltd}, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and F. Lorussi and R. Paradiso and E. P. Scilingo and A. Tognetti} } @conference {1268, title = {Functional and Pharmacological testing of endothelial cells cultured in dynamic conditions}, booktitle = {Proceedings of: XIV Edizione del Congresso della Fisiologia Clinica-CNR}, year = {2005}, pages = {82-96}, keywords = {Bioengineering}, author = {Vozzi, F. and Gentile, C. and D. Mazzei and G. Vozzi and C. Domenici and A. Ahluwalia} } @article {1280, title = {Osmolality control by inhalation or micro-infusions?}, journal = {WIT Transactions on Biomedicine and Health}, volume = {9}, year = {2005}, pages = {559-570}, abstract = {

A model of osmolarity is proposed in this paper. This model represents a typical example of embedded physiological feedback control in physiology. Extensive simulation tests with a compartmental approach (using the specific software SAAM II) have been performed, showing that the model agrees with the findings published in the literature of endocrine physiology and with medical practice. As a relevant example of application of the models, the diabetes insipidus pathology was considered. In the case of central insipidus diabetes, it is possible to predict effects of a therapy, giving out synthetic ADH (where ADH is the antidiuretic hormone, the vasopressine) for restoring homeostatic conditions. Two kinds of therapy were considered: supply by inhalation or by microinfusion. In the first case, we evaluated the effect of inhalation using a two compartmental model to describe the effect of commercial drug (minirin, that means desmopressine acetate), and compared results with data existing in the literature. In the second case, the aim was to have a helping tool in the study and development of micro-infusors with sensors and controllers embedded so as to be able to release a controlled drug quantity, accorded to the patient and optimized for avoiding hyper- or ipo-concentrations of plasma ADH hormone. In this case, we used a mono-compartmental model, considering that the drug is infused directly in the plasma; results are again compared with data existing in the literature and with experimental data.

}, keywords = {Bioengineering}, author = {Ciofani, G. and A. Landi and D. Mazzei and A. Mazzoldi} } @article {SGPTGD05, title = {Performance evaluation of Sensing Fabrics for Monitoring Physiological and Biomechanical Variables}, journal = {IEEE Transactions on Information Technology in BioMedicine}, volume = {9}, number = {3}, year = {2005}, month = {September}, pages = {345-352}, keywords = {Bioengineering}, author = {E. P. Scilingo and A. Gemignani and R. Paradiso and N. Taccini and B. Ghelarducci and D. De Rossi} } @conference {1266, title = {Physiological Cybernetics: Model of Osmolality and Volemia}, booktitle = {Proc. and 2005 European Control Conf. Decision and Control CDC-ECC {\textquoteright}05. 44th IEEE Conf}, year = {2005}, pages = {5552{\textendash}5557}, keywords = {Bioengineering}, doi = {10.1109/CDC.2005.1583046}, author = {Ciofani, G. and A. Landi and D. Mazzei and A. Mazzoldi} } @article {DCS05, title = {Polymers based interfaces as bioninspired {\textquoteright}smart skins{\textquoteright}}, journal = {Advances in Colloids and Interface Science}, volume = {116}, year = {2005}, month = {August}, pages = {165-178}, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and E. P. Scilingo} } @conference {1267, title = {Realisation of a concentration gradients cell chamber to study their effect of biomolecules on the cell activity}, booktitle = {Proceedings of: 4Th Annual Meeting of the European Tissue Engineering Society (ETES)}, year = {2005}, keywords = {Bioengineering}, author = {D. Mazzei and Vozzi, F. and G. Vozzi and A. Ahluwalia} } @article {LSTTD05, title = {Strain sensing fabric for hand posture and gesture monitoring}, journal = {IEEE Transactions on Information Technology in BioMedicine}, volume = {9}, number = {3}, year = {2005}, month = {September}, pages = {372-381}, keywords = {Bioengineering}, author = {F. Lorussi and E. P. Scilingo and M. Tesconi and A. Tognetti and D. De Rossi} } @conference {BPMLSC-04, title = {Analysis Of Heart Rate And Respiration Variability Signals Obtained Through A Wearable System}, booktitle = {Mediterranean Conference on Medical and Biological Engineering}, year = {2004}, month = {August}, address = {Island of Ischia, Italy}, keywords = {Bioengineering}, author = {R. Paradiso and M. O. Mendez and G. Loriga and E. P. Scilingo and S. Cerutti} } @inbook {DLSCTT04, title = {Artificial kinesthetic systems for telerehabilitation}, booktitle = {Wearable eHealth Systems for Personalised Health Management}, year = {2004}, pages = {209-213}, publisher = {IOS Press}, organization = {IOS Press}, keywords = {Bioengineering}, author = {D. De Rossi and F. Lorussi and E. P. Scilingo and Carpi, F and A. Tognetti and Tesconi, M} } @conference {CPTSLDGGBVG-04, title = {Development of a Wearable System Based on Smart Textiles and GPRS Transmission for Remote Multiparametric Monitoring of Cardiac Patients: Preliminary Results of the WEALTHY Project}, booktitle = {THE 5th International Heart Health Conference}, year = {2004}, month = {June}, address = {Milan, Italy}, keywords = {Bioengineering}, author = {S. Coli and R. Paradiso and N. Taccini and E. P. Scilingo and G. Loriga and D. De Rossi and A. Gemignani and B. Ghelarducci and L. Bourdon and A. Ditmar and T. Vavouras and B. Gros and J. Luprano and M. Jaenecke and C. Coucke and G. Delhomme and D. Cianflone} } @inbook {S04, title = {I Sensori fisici}, booktitle = {Sensori per Misure Biomediche}, year = {2004}, pages = {59-107}, publisher = {Patron}, organization = {Patron}, keywords = {Bioengineering}, author = {E. P. Scilingo} } @conference {GSLTPD-04, title = {A sensing shirt for monitoring behavioral and autonomic parameters}, booktitle = {55}, year = {2004}, month = {February}, pages = {83}, address = {Innsbruck, Austria}, keywords = {Bioengineering}, author = {A. Gemignani and E. P. Scilingo and G. Loriga and N. Taccini and R. Paradiso and D. De Rossi and B. Ghelarducci} } @conference {DLSCTTO-04, title = {An Upper Limb Kinesthetic-Like System For Tele-Rehabilitation}, booktitle = {Mediterranean Conference on Medical and Biological Engineering}, year = {2004}, month = {August}, address = {Island of Ischia, Italy}, keywords = {Bioengineering}, author = {D. De Rossi and F. Lorussi and E. P. Scilingo and F. Carpi and M. Tesconi and A. Tognetti and P. Orsini} } @article {LRSTD04, title = {Wearable, Redundant Fabric-Based Sensor Arrays for Reconstruction of Body Segment Posture}, journal = {IEEE Sensors Journal}, volume = {4}, number = {6}, year = {2004}, month = {December}, pages = {807-818}, keywords = {Bioengineering}, author = {F. Lorussi and W. Rocchia and E. P. Scilingo and A. Tognetti and D. De Rossi} } @inbook {DLMOS03, title = {Active dressware: wearable kinesthetic systems}, booktitle = {Sensor and sensing in biology and engineering}, year = {2003}, pages = {379-392}, publisher = {Springer Wien}, organization = {Springer Wien}, keywords = {Bioengineering}, author = {D. De Rossi and F. Lorussi and A. Mazzoldi and P. Orsini and E. P. Scilingo} } @conference {DLS-03, title = {Artificial kinesthetic systems for telerehabilitation}, booktitle = {International Workshop in New generation of wearable systems for e-Health: towards a revolution of citizen{\textquoteright} health and life style management?}, year = {2003}, month = {December}, pages = {129-133}, address = {Lucca, Italy}, keywords = {Bioengineering}, author = {D. De Rossi and F. Lorussi and E. P. Scilingo} } @article {DCLMPS03, title = {Electroactive Fabrics And Wearable Biomonitoring Devices}, journal = {AUTEX Research Journal}, volume = {3}, number = {4}, year = {2003}, month = {December}, pages = {180-185}, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and F. Lorussi and A. Mazzoldi and R. Paradiso and E. P. Scilingo and A. Tognetti} } @conference {PGSD-03, title = {Knitted Bioclothes for Cardiopulmonary Monitoring}, booktitle = {25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society}, year = {2003}, month = {September}, pages = {3720-3723}, address = {Cancun,Mexico}, keywords = {Bioengineering}, author = {R. Paradiso and A. Gemignani and E. P. Scilingo and D. De Rossi} } @article {SLMD03, title = {Strain-Sensing Fabrics for Wearable Kinaesthetic-Like Systems}, journal = {IEEE Sensors Journal}, volume = {3}, number = {4}, year = {2003}, month = {August}, pages = {460-467}, keywords = {Bioengineering}, author = {E. P. Scilingo and F. Lorussi and A. Mazzoldi and D. De Rossi} } @conference {LSTTD-03, title = {Wearable Sensing Garment For Posture Detection, Rehabilitation And Tele-Medicine}, booktitle = {4th International IEEE EMBS Special Topic Conference on Information Technology Applications in Biomedicine}, year = {2003}, month = {April}, pages = {287-290}, address = {Birmingham,UK}, keywords = {Bioengineering}, author = {F. Lorussi and E. P. Scilingo and M. Tesconi and A. Tognetti and D. De Rossi} } @conference {TCLMOSTD-03, title = {Wearable Sensory-Motor Orthoses for Tele-Rehabilitation}, booktitle = {25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society}, year = {2003}, month = {September}, pages = {3724-3727}, address = {Cancun,Mexico}, keywords = {Bioengineering}, author = {A. Tognetti and F. Carpi and F. Lorussi and A. Mazzoldi and P. Orsini and E. P. Scilingo and M. Tesconi and D. De Rossi} } @conference {DLMOS-02, title = {Active dressware: Wearable kinestetic system}, booktitle = {International Interactive Textiles for the Warrior Conference}, year = {2002}, month = {July}, address = {Boston, USA}, keywords = {Bioengineering}, author = {D. De Rossi and F. Lorussi and A. Mazzoldi and P. Orsini and E. P. Scilingo} } @conference {DCLMST-02, title = {Electroactive Fabrics for Distributed, Conformable and Interactive Systems}, booktitle = {The first IEEE International Conference on Sensors}, year = {2002}, month = {June}, pages = {1608-1613}, address = {Orlando, Florida}, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and F. Lorussi and A. Mazzoldi and E. P. Scilingo and A. Tognetti} } @conference {DCLMST-02, title = {Electroactive Fibers and Fabrics for Distributed, Conformable and Interactive Systems}, booktitle = {Proceedings of the First European Workshop on Structural Health Monitoring}, year = {2002}, month = {July}, address = {Cachan, France}, keywords = {Bioengineering}, author = {D. De Rossi and F. Carpi and F. Lorussi and A. Mazzoldi and E. P. Scilingo and A. Tognetti} } @conference {SLDPGPAGG-02, title = {A Sensing Shirt for Monitoring Body Kinematic and Vital Signs}, booktitle = {Symposium on Telemedicine In Care Delivery, Technology and Application}, year = {2002}, month = {June}, pages = {57-67}, address = {Pisa, Italy}, keywords = {Bioengineering}, author = {E. P. Scilingo and F. Lorussi and D. De Rossi and R. Paradiso and M. Ghignoli and M. Pacelli and G. Anerdi and A. Gemignani and B. Ghelarducci} } @article {MDLSP02, title = {Smart textiles for wearable motion capture systems}, journal = {AUTEX Research Journal}, volume = {2}, number = {4}, year = {2002}, month = {December}, pages = {199-203}, keywords = {Bioengineering}, author = {A. Mazzoldi and D. De Rossi and F. Lorussi and E. P. Scilingo and R. Paradiso} } @conference {PGPALSDO-02, title = {A wearable motion capture system for multimedia applications}, booktitle = {Avantex Symposium - International Forum for Textiles and Technology in the Future}, year = {2002}, month = {May}, address = {Frankfurt, Germany}, keywords = {Bioengineering}, author = {R. Paradiso and M. Ghignoli and M. Pacelli and G. Anerdi and F. Lorussi and E. P. Scilingo and D. De Rossi and P. Orsini} } @conference {DLMWS-01, title = {Strain-amplified electroactive polymer actuator for haptic interfaces}, booktitle = {Proceedings of SPIE}, year = {2001}, month = {July}, pages = {43-53}, address = {Newport Beach, USA}, keywords = {Bioengineering, Haptics}, author = {D. De Rossi and F. Lorussi and A. Mazzoldi and W. Rocchia and E. P. Scilingo} } @conference {SB-01, title = {Tactile Flow: Does it exist, is it useful and how?}, booktitle = {Proc. Int. Worksh. on Electroactive Polymers and Biosystems}, year = {2001}, month = {July}, pages = {142}, address = {Lucca, Italy}, keywords = {Bioengineering, Haptics, Robotics}, author = {E. P. Scilingo and A. Bicchi} } @conference {BDRS99, title = {Psychophysical Evaluation of Simplified Haptic Perception Media}, booktitle = {Proc. Int. Workshop on Robot and Human Interaction}, year = {1999}, month = {September}, address = {Pisa}, abstract = {

Detection of softness by tactile exploration in humans is based on both kinesthetic and cutaneous perception, and haptic displays should be designed so as to address such multimodal perceptual channel. Unfortunately, accurate detection and replication of cutaneous information in all its details is difficlt and costly. In this paper we discuss a simplified model of haptic detection of softness (whereby only information on the rate of spread of the contact area between the finger and the specimen as the contact force increases is transmitted). We provide a thorough set of psychophysical tests, to support the feasibility (in at least some contexts) of a reduced-complicacy display of haptic features.

}, keywords = {Bioengineering, Haptics, Robotics}, author = {A. Bicchi and D. De Rossi and E. P. Scilingo} } @conference {ABDRS99, title = {The Role of Contact Area Spread Rate in Haptic Discrimination of Softness}, booktitle = {Proc. IEEE Int. Conf. on Robotics and Automation}, year = {1999}, pages = {305-310}, abstract = {

Many applications in teleoperation and virtual reality call for the implementation of effective means of displaying to the human operator information on the softness and other mechanical properties of objects being touched. The ability of humans to detect softness of different objects by tactual exploration is intimately related to both kinesthetic and cutaneous perception, and haptic displays should be designed so as to address such multimodal perceptual channel. Unfortunately, accurate detection and replication of cutaneous information in all its details appears to be a formidable task for current technology, causing most of today{\textquoteright}s haptic displays to merely address the kinesthetic part of haptic information. In this paper we investigate the possibility of surrogating detailed tactile information for softness discrimination, with information on the rate of spread of the contact area between the finger and the specimen. Devices for implementing this new perceptual channel are described, and some preliminary psychophysical test results are reported, validating the effectiveness and practicality of the proposed approach.

}, keywords = {Bioengineering, Haptics, Robotics}, author = {G. Ambrosi and A. Bicchi and D. De Rossi and E. P. Scilingo} } @conference {SBDRI-98, title = {Haptic display able to replicate the rheological behaviour of surgical tissues}, booktitle = {Proc. 20th International Conference IEEE/EMBS}, year = {1998}, pages = {1738-1741}, address = {Hong Kong}, keywords = {Bioengineering, Haptics, Robotics}, author = {E. P. Scilingo and A. Bicchi and D. De Rossi and P. Iacconi} } @conference {SDRBI97-ASME, title = {Haptic display for replication of rheological behaviour of surgical tissues: modelling, control, and experiments}, booktitle = {Proc. Annual ASME Symp. on Haptic Interfaces for Virtual Environments and Teleoperator Systems}, year = {1997}, address = {Dallas}, keywords = {Bioengineering, Haptics, Robotics}, author = {E. P. Scilingo and D. De Rossi and A. Bicchi and P. Iaccone} } @article {1777, title = {Need better sensor: try using polymers}, journal = {RESEARCH \& DEVELOPMENT}, year = {1989}, pages = {66{\textendash}70}, keywords = {Bioengineering}, issn = {0746-9179}, author = {D. De Rossi} } @article {1776, title = {Shear stress detection in an elastic layer by a piezoelectric polymer tactile sensor}, journal = {IEEE TRANSACTIONS ON ELECTRICAL INSULATION}, volume = {24}, year = {1989}, pages = {1077{\textendash}1081}, keywords = {Bioengineering}, issn = {0018-9367}, author = {C. Domenici and D. De Rossi and A. Bacci and S. Bennati} } @article {1775, title = {Tactile sensing by an electromechanochemical skin analog}, journal = {SENSORS AND ACTUATORS}, volume = {17}, year = {1989}, pages = {107{\textendash}114}, keywords = {Bioengineering}, issn = {0250-6874}, author = {D. De Rossi and L. Lazzeri and C. Domenici and A. Nannini and P. Basser} } @article {1774, title = {Artificial sensing skin mimicking mechanoelectrical conversion properties of human dermis}, journal = {IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING}, volume = {35}, year = {1988}, pages = {83{\textendash}92}, keywords = {Bioengineering}, issn = {0018-9294}, author = {D. De Rossi and A. Nannini and C. Domenici} } @article {1773, title = {Determination of mechanical parameters related to the kinetics of swelling in an electrically activated contractile gel}, journal = {PROGRESS IN COLLOID \& POLYMER SCIENCE}, volume = {78}, year = {1988}, pages = {4{\textendash}8}, keywords = {Bioengineering}, issn = {0340-255X}, author = {Chiarelli, P and D. De Rossi} } @article {1770, title = {A Biomimetic tactile array with stress-component-selective sensing capabilities}, journal = {MATERIALS SCIENCE}, volume = {13}, year = {1987}, pages = {47{\textendash}50}, keywords = {Bioengineering}, issn = {0137-1339}, author = {D. De Rossi and C. Domenici and A. Nannini and R. Francesconi} } @article {1769, title = {Biomimetic tactile sensor with stress-component-discrimination capability}, journal = {JOURNAL OF MOLECULAR ELECTRONICS}, volume = {3}, year = {1987}, pages = {173{\textendash}181}, keywords = {Bioengineering}, issn = {0748-7991}, author = {D. De Rossi and A. Nannini and C. Domenici} } @article {1768, title = {Measurement of the hydrostatic piezoelectric, coefficient using a {\^A}{\textmu}P based apparatus}, journal = {FERROELECTRICS}, volume = {76}, year = {1987}, pages = {283{\textendash}290}, keywords = {Bioengineering}, issn = {0015-0193}, author = {C. Domenici and A. Nannini and D. De Rossi} } @article {1771, title = {NTIR Optical Immunosensor}, journal = {MEDICINE BIOLOGIE ENVIRONMENT}, volume = {15}, year = {1987}, pages = {49{\textendash}54}, keywords = {Bioengineering}, author = {M. Monici and A. Nannini and D. De Rossi} } @article {1765, title = {Approccio bionico allo sviluppo di trasduttori tattili ed attuatori lineari per robotica avanzata}, journal = {ALTA FREQUENZA}, volume = {55}, year = {1986}, pages = {55{\textendash}62}, keywords = {Bioengineering}, issn = {0002-6557}, author = {D. De Rossi and C. Domenici and Chiarelli, P} } @article {1764, title = {Design criteria for ferroelectric polymer sensors and their applications to artificial organ technology}, journal = {ASAIO TRANSACTIONS}, volume = {32}, year = {1986}, pages = {697{\textendash}701}, keywords = {Bioengineering}, issn = {0889-7190}, author = {D. De Rossi} } @article {1766, title = {Effetti di osteosintesi endomidollari a polimeri piezoelettrico: ricerca sperimentale}, journal = {ORTOPEDIA E TRAUMATOLOGIA OGGI}, volume = {4}, year = {1986}, pages = {229{\textendash}232}, keywords = {Bioengineering}, issn = {0392-1417}, author = {F. Carlucci and P. Puntoni and ARISPICI, M and M. Cecconi and C. Domenici and P. Dario and D. De Rossi} } @article {1762, title = {Indwelling acoustic sensors for early detection of total artificial heart failure}, journal = {LIFE SUPPORT SYSTEMS}, volume = {4}, year = {1986}, pages = {239{\textendash}248}, keywords = {Bioengineering}, issn = {0261-989X}, author = {Y. L. Sheng and D. De Rossi and P. Dario and P.M. Galletti} } @article {1767, title = {Piezoelectric properties of dry human skin}, journal = {IEEE TRANSACTIONS ON ELECTRICAL INSULATION}, volume = {EI-21}, year = {1986}, pages = {511{\textendash}517}, keywords = {Bioengineering}, issn = {0018-9367}, author = {D. De Rossi and C. Domenici and P. Pastacaldi} } @article {1749, title = {Electrically induced contractile phenomena in charged polymer networks: preliminary study on the feasibility of muscle-like structures}, journal = {TRANSACTIONS - AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS}, volume = {31}, year = {1985}, pages = {60{\textendash}65}, keywords = {Bioengineering}, issn = {0066-0078}, author = {D. De Rossi and P. Parrini and Chiarelli, P and G. Buzzigoli} } @article {1750, title = {Tactile sensors and the gripping challenge}, journal = {IEEE SPECTRUM}, volume = {22}, year = {1985}, pages = {46{\textendash}52}, keywords = {Bioengineering}, issn = {0018-9235}, author = {P. Dario and D. De Rossi} } @article {1747, title = {Alcuni fenomeni di traduzione meccanoelettrica in materiali organici di sintesi: propriet{\~A} e analogie con meccanismi di origine biologica}, journal = {L{\textquoteright}ELETTROTECNICA}, volume = {80}, year = {1984}, pages = {619{\textendash}631}, keywords = {Bioengineering}, issn = {0013-6131}, author = {D. De Rossi and P. Dario and C. Domenici and P. Parrini} } @article {1743, title = {Ferroelectric polymer tactile sensors for prostheses}, journal = {FERROELECTRICS}, volume = {60}, year = {1984}, pages = {199{\textendash}214}, keywords = {Bioengineering}, issn = {0015-0193}, author = {P. Dario and D. De Rossi and C. Giannotti and F. Vivaldi and P. C. Pinotti} } @article {1744, title = {Multisensor piezoelectric polymer insole for pedobarography}, journal = {FERROELECTRICS}, volume = {60}, year = {1984}, pages = {163{\textendash}174}, keywords = {Bioengineering}, issn = {0015-0193}, author = {A. Pedotti and R. Assente and G. Fusi and D. De Rossi and P. Dario and C. Domenici} } @article {1741, title = {Piezoelectric properties and dielectric losses in PVDF-PMMA blends}, journal = {FERROELECTRICS}, volume = {60}, year = {1984}, pages = {61{\textendash}70}, keywords = {Bioengineering}, issn = {0015-0193}, author = {C. Domenici and D. De Rossi and A. Nannini and R. Verni} } @article {1742, title = {Prime esperienze sull{\textquoteright}impiego di un polimero piezoelettrico (PVF2) nella riparazione di fratture sperimentali nel ratto}, journal = {ANNALI DELLE FACOLT{\~A}? DI MEDICINA VETERINARIA}, volume = {34}, year = {1984}, pages = {47{\textendash}60}, keywords = {Bioengineering}, issn = {0390-4660}, author = {F. Carlucci and P. Puntoni and ARISPICI, M and M. Cecconi and C. Domenici and P. Dario and D. De Rossi} } @article {1740, title = {Prosthetic vascular graft monitoring by ultrasound using piezoelectric polymers (PZP)}, journal = {TRANSACTIONS - AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS}, volume = {30}, year = {1984}, pages = {{\textendash}}, keywords = {Bioengineering}, issn = {0066-0078}, author = {P. Dario and P.D. Richardson and M. Bertoncini and D. De Rossi and L.A. Trudell and P.M. Galletti} } @article {1745, title = {PVF2 Catheter-tip transducers for pressure, sound and flow measurement}, journal = {FERROELECTRICS}, volume = {60}, year = {1984}, pages = {149{\textendash}162}, keywords = {Bioengineering}, issn = {0015-0193}, author = {P. Dario and D. De Rossi and R. Bedini and R. Francesconi and M.G. Tivella} } @article {1748, title = {Pyroelectric sensing station for automatic recognition of position and orientation of objects}, journal = {INTERNATIONAL JOURNAL OF MACHINE TOOL DESIGN \& RESEARCH}, volume = {24}, year = {1984}, pages = {145{\textendash}160}, keywords = {Bioengineering}, issn = {0020-7357}, author = {L.R Wang and P. Dario and D. De Rossi and R. Francesconi and P. C. Pinotti} } @article {1746, title = {Sensori tattili a polimeri ferroelettrici}, journal = {TECNICHE DELL{\textquoteright}AUTOMAZIONE \& ROBOTICA}, volume = {7-8}, year = {1984}, pages = {25{\textendash}29}, keywords = {Bioengineering}, issn = {1721-7563}, author = {P. Dario and D. De Rossi and C. Domenici and P. C. Pinotti} } @article {1738, title = {Biomedical applications of piezoelectric and pyroelectric polymers}, journal = {FERROELECTRICS}, volume = {49}, year = {1983}, pages = {49{\textendash}58}, keywords = {Bioengineering}, issn = {0015-0193}, author = {D. De Rossi and P. Dario} } @article {1739, title = {The electromechanical connection: piezoelectric polymers in artificial organs}, journal = {TRANSACTIONS - AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS}, volume = {6}, year = {1983}, pages = {1{\textendash}11}, keywords = {Bioengineering}, issn = {0066-0078}, author = {D. De Rossi and P.M. Galletti and P. Dario and P.D. Richardson} } @article {1737, title = {Method of evaluating the thermal stability of the pyroelectric properties of polyvinylidene fluoride: effects of poling temperature and field}, journal = {JOURNAL OF APPLIED PHYSICS}, volume = {53}, year = {1982}, pages = {6520{\textendash}6525}, keywords = {Bioengineering}, issn = {0021-8979}, author = {D. De Rossi and A. S. De Reggi and M. G. Broadhurst and S. C. Roth and G. T. Davis} } @article {1735, title = {Recent developments in biomedical signal transduction techniques}, journal = {ELETTROMEDICALI}, volume = {2}, year = {1982}, pages = {76{\textendash}91}, keywords = {Bioengineering}, issn = {0393-7070}, author = {P. Dario and D. De Rossi} } @article {1736, title = {Techniques and transducers for non-invasive measurement of physiological parameters}, journal = {ELETTROMEDICALI}, volume = {2}, year = {1982}, pages = {59{\textendash}75}, keywords = {Bioengineering}, issn = {0393-7070}, author = {D. De Rossi} } @article {1733, title = {Touch-sensitive polymer skin uses piezoelectric properties to recognize orientation of objects}, journal = {SENSOR REVIEW}, volume = {4}, year = {1982}, pages = {194{\textendash}198}, keywords = {Bioengineering}, issn = {0260-2288}, author = {P. Dario and R. Bardelli and D. De Rossi and L.R Wang and P. C. Pinotti} } @article {1734, title = {Trasduttori acustici a polimeri piezoelettrici}, journal = {RIVISTA ITALIANA DI ACUSTICA}, volume = {4}, year = {1982}, pages = {121{\textendash}141}, keywords = {Bioengineering}, issn = {0393-1110}, author = {D. De Rossi and R. Bardelli and P. Dario and C. Domenici and F. Pedrini} } @article {1732, title = {Modular hydropneumatic mock circulatory system for the evaluation of cardiovascular prostheses,}, journal = {TRANSACTIONS - AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS}, volume = {4}, year = {1981}, pages = {139{\textendash}148}, keywords = {Bioengineering}, issn = {0066-0078}, author = {G. Nardi and S. Cicconardi and P. Dario and D. De Rossi} } @article {1731, title = {A new fibre-optic liquid crystal catheter for oxygen saturation and blood flow measurement in the coronary sinus}, journal = {JOURNAL OF BIOMEDICAL ENGINEERING}, volume = {2}, year = {1980}, pages = {257{\textendash}264}, keywords = {Bioengineering}, issn = {0141-5425}, author = {D. De Rossi and A. Benassi and A. L{\textquoteright}Abbate and P. Dario} } @article {1730, title = {A liquid crystal fiberoptic catheter for blood flow measurement by thermodilution}, journal = {JOURNAL OF NUCLEAR MEDICINE AND ALLIED SCIENCES}, volume = {23}, year = {1979}, pages = {173{\textendash}177}, keywords = {Bioengineering}, issn = {0392-0208}, author = {P. Dario and D. De Rossi and A. Riva and A. Benassi and A. L{\textquoteright}Abbate} } @article {1728, title = {Dispositivo a cristalli liquidi per la realizzazione di maschere ad oscuramento pilotato nella saldatura elettrica}, journal = {RIVISTA ITALIANA DELLA SALDATURA}, volume = {6}, year = {1978}, pages = {359{\textendash}366}, keywords = {Bioengineering}, issn = {0035-6794}, author = {R. Bedini and D. De Rossi} } @article {1729, title = {Electro-optic behaviour of a field-induced twisted structure with quasi homeotropic boundary conditions}, journal = {JOURNAL OF APPLIED PHYSICS}, volume = {49}, year = {1978}, pages = {1139{\textendash}1142}, keywords = {Bioengineering}, issn = {0021-8979}, author = {D. De Rossi and J. Robert} } @article {1727, title = {An introduction to medical thermography}, journal = {JOURNAL OF NUCLEAR MEDICINE AND ALLIED SCIENCES}, volume = {21}, year = {1977}, pages = {5{\textendash}6}, keywords = {Bioengineering}, issn = {0392-0208}, author = {D. De Rossi} }